2-methyl-6-phenyl-4-(2-phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-ethyl ester O5-[(4-nitrophenyl)methyl] ester

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-methyl-6-phenyl-4-(2-phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-ethyl ester O5-[(4-nitrophenyl)methyl] ester
• 英文别名: 3-O-ethyl 5-O-[(4-nitrophenyl)methyl] 2-methyl-6-phenyl-4-(2-phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 化学式: C31H26N2O6
• 分子量: 522.5
• InChiKey: QFLOJAMZLQXHFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Methods for reducing intraocular pressure
  申请人：——

  公开号：US20030153626A1

  公开（公告）日：2003-08-14

  A method for decreasing intraocular pressure by administering an A 3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen. These agents, by inhibiting influx or promoting efflux of aqueous humor, can be used to treat glaucoma.

  一种通过施用 A 3 亚型腺苷受体拮抗剂、钙调素拮抗剂或抗雌激素（如他莫昔芬）来降低眼压的方法。这些药物通过抑制房水的流入或促进房水的流出，可用于治疗青光眼。
• METHODS FOR REDUCING INTRAOCULAR PRESSURE USING A3-ADENOSINE ANTAGONISTS
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：EP1096975A2

  公开（公告）日：2001-05-09
• USE OF A3 ADENOSINE RECEPTOR ANTAGONISTS IN THE MANUFACTURE OF A MEDICAMENT FOR REDUCING INTRAOCULAR PRESSURE
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：EP1096975B1

  公开（公告）日：2005-03-16
• US6528516B1
  申请人：——

  公开号：US6528516B1

  公开（公告）日：2003-03-04
• [EN] METHODS FOR REDUCING INTRAOCULAR PRESSURE<br/>[FR] PROCEDES DE REDUCTION DE LA PRESSION INTRA-OCULAIRE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2000003741A2

  公开（公告）日：2000-01-27

  A method for decreasing intraocular pressure by administering an A3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen. These agents, by inhibiting influx or promoting efflux of aqueous humor, can be used to treat glaucoma.