(E)-4-amino-2,5-hexadienoic acid | 102420-40-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-4-amino-2,5-hexadienoic acid
• 英文别名: (2E)-4-aminohexa-2,5-dienoic acid
• CAS: 102420-40-6
• 化学式: C₆H₉NO₂
• 分子量: 127.143
• InChiKey: ULEJSYZOLPJROT-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl (2E,4E)-6-hydroxy-2,4-hexadienoate 在 盐酸 、 sodium hydroxide 、 sodium chlorite 、 sodium dihydrogenphosphate 、 lithium aluminium tetrahydride 、 jones' reagent 、 4-甲基苯磺酸吡啶 、 sodium hydride 、 甲烷 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 乙醇 、 二氯甲烷 、 水 、 丙酮 、 xylene 、 叔丁醇 为溶剂， 反应 61.33h， 生成 (E)-4-amino-2,5-hexadienoic acid
  参考文献：
  名称：

  Synthesis of (E)-4-amino-2,5-hexadienoic acid and (E)-4-amino-5-fluoro-2-pentenoic acid. Irreversible inhibitors of 4-aminobutyrate-2-oxoglutarate aminotransferase

  摘要：

  DOI：

  10.1021/jo00364a049

文献信息

• [EN] FLUORINE SUBSTITUTED CECLOHEXENE ANALOGOUES OF GAMMA-AMINOBUTYRIC ACID (GABA)<br/>[FR] ANALOGUES DE CYCLOHEXÈNE SUBSTITUÉS PAR DU FLUOR DE L'ACIDE GAMMA-AMINOBUTYRIQUE (GABA)
  申请人：UNIV NORTHWESTERN

  公开号：WO2021081523A1

  公开（公告）日：2021-04-29

  Disclosed are amino, fluoro-sub stituted cyclohexene carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating ornithine aminotransferase (OAT) activity, including methods for treating diseases or disorders associated with OAT activity or expression such as cell proliferative diseases and disorders.

  本文披露了氨基，氟代取代的环己烯羧酸化合物。所披露的化合物及其组合物可用于调节鸟氨酸氨基转移酶（OAT）活性的方法，包括用于治疗与OAT活性或表达相关的疾病或障碍的方法，如细胞增殖性疾病和障碍。
• ELECTRICALLY CONDUCTIVE MATERIAL AND LAMINATE
  申请人：PIOTREK CO., LTD.

  公开号：EP3211033A1

  公开（公告）日：2017-08-30

  Problems to be solved by this invention This invention proposes a conductive material and multilayered structure having an excellent conductivity, an excellent durable conductivity and also strength. Further, this invention proposes a multilayered structure having an excellent conductivity, an excellent durable conductivity and also strength comprising laminating the conductive material to one side surface or both surfaces of the non-conductive material layer. The above purpose is accomplished by providing a conductive material comprising a polymer electrolyte composition (X1) obtained by graft polymerizing 2 to 90 mol.% of a molten salt monomer having a polymerizable functional group and having an onium cation and anion containing a fluorine with a fluorine containing polymer and a fluoropolymer (X2) wherein X1 contains 0.1 to 95A wt.% to X2.

  本发明要解决的问题 本发明提出了一种导电材料和多层结构，具有优异的导电性、优异的耐久导电性和强度。 此外，本发明还提出了一种具有优异导电性、持久导电性和强度的多层结构，包括将导电材料层压到非导电材料层的一侧表面或两侧表面。 为实现上述目的，本发明提供了一种导电材料，该导电材料包含一种聚合物电解质组合物（X1），该聚合物电解质组合物是通过将 2 至 90 mol.% 的具有可聚合官能团且具有含氟的鎓阳离子和阴离子的熔盐单体与含氟聚合物和含氟聚合物（X2）进行接枝聚合而得到的，其中 X1 与 X2 的重量比为 0.1 至 95A。
• Water-soluble stabilized self-assembled polyelectrolytes
  申请人：——

  公开号：US20030059398A1

  公开（公告）日：2003-03-27

  The present invention is directed toward water-soluble supramolecular self-assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophilic polymers or oligomers. It has been determined that the inclusion of the hydrophobic co-monomers to the polyelectrolyte segment forming the micelle core leads to a structure of enhanced stability.

  本发明针对的是水溶性超分子自组装体，以及通过使用疏水性单体单元使聚电解质胶束化来制备超分子自组装体的工艺。在本发明中，聚电解质部分最终形成超分子组装体的核心，而外壳则由不带电的亲水性聚合物或低聚物组成。经确定，在形成胶束核心的聚电解质段中加入疏水性共聚单体可提高结构的稳定性。
• Taste masked pharmaceutical composition comprising pH sensitive polymer
  申请人：Kulkarni Gopalkrishna Mohan

  公开号：US20050136115A1

  公开（公告）日：2005-06-23

  The present invention discloses a substantially amorphous pharmaceutical composition comprising a drug that can exist in a variety of polymorphic forms and a pH sensitive polymer, which inhibits the crystallization of the drug during formulation and reconstitution. Polymers of higher molecular weight are more effective at lower loading, especially when the drug polymer matrix is prepared by the solvent evaporation or solvent extraction technique. The compositions used as dry syrups maintain bioavailability of the drug and effectively mask the taste of the drug when the composition is reconstituted.

  本发明公开了一种基本无定形的药物组合物，该组合物包含一种可以以多种多晶体形式存在的药物和一种对 pH 值敏感的聚合物，后者可以在配制和复溶过程中抑制药物结晶。分子量较高的聚合物在较低的负载量下更有效，特别是当药物聚合物基质是通过溶剂蒸发或溶剂萃取技术制备时。作为干糖浆使用的组合物可以保持药物的生物利用度，并在组合物重组时有效掩盖药物的味道。
• pH sensitive polymer and process for preparation thereof
  申请人：Kulkarni G. Mohan

  公开号：US20050137372A1

  公开（公告）日：2005-06-23

  The present invention relates a novel pH sensitive polymer which exhibits pH dependant swelling/dissolution behavior. The composition is useful for taste masking of bitter drugs and also for the gastric delivery of the drugs. The said polymer comprises a hydrophobic monomer polymerized along with a basic monomer or a hydrophobic monomer polymerized along with a basic monomer and a hydrophilic monomer.

  本发明涉及一种新型 pH 值敏感聚合物，其膨胀/溶解行为与 pH 值有关。该组合物可用于掩盖苦味药物的味道，也可用于胃肠道给药。所述聚合物由疏水单体与碱性单体聚合而成，或由疏水单体与碱性单体和亲水单体聚合而成。