1-(2-chlorophenyl)-4-methyl-1H-1,2,3-triazole-5-carboxylic acid | 1362020-71-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-chlorophenyl)-4-methyl-1H-1,2,3-triazole-5-carboxylic acid
• 英文别名: 3-(2-Chlorophenyl)-5-methyltriazole-4-carboxylic acid
• CAS: 1362020-71-0
• 化学式: C₁₀H₈ClN₃O₂
• 分子量: 237.645
• InChiKey: PIIDNEBIHAJUTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-chlorophenyl)-4-methyl-1H-1,2,3-triazole-5-carboxylic acid 、 1-(2-氯-4-硝基苯基)哌嗪 在 草酰氯 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以72.3%的产率得到(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(2-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone
  参考文献：
  名称：

  Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein

  摘要：

  The influenza virus nucleoprotein (NP) is an emerging target for anti-influenza drug development. Nucleozin (1) and its closely related derivatives had been identified as NP inhibitors displaying anti-influenza activity. Utilizing 1 as a lead molecule, we successfully designed and synthesized a series of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents. One of the most potent compounds, 3b, inhibited the replication of various H3N2 and H1N1 influenza A virus strains with IC50 values ranging from 0.5 to 4.6 mu M. Compound 3b also strongly inhibited the replication of H5N1 (RG14), amantidine-resistant A/WSN/33 (H1N1), and oseltamivir-resistant A/WSN/1933 (H1N1, 274Y) virus strains with IC50 values in sub-mu M ranges. Further computational studies and mechanism investigation suggested that 3b might directly target influenza virus A nucleoprotein to inhibit its nuclear accumulation.

  DOI：

  10.1021/jm2013503
• 作为产物：
  描述：

  1-叠氮基-2-氯苯 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 生成 1-(2-chlorophenyl)-4-methyl-1H-1,2,3-triazole-5-carboxylic acid
  参考文献：
  名称：

  Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein

  摘要：

  The influenza virus nucleoprotein (NP) is an emerging target for anti-influenza drug development. Nucleozin (1) and its closely related derivatives had been identified as NP inhibitors displaying anti-influenza activity. Utilizing 1 as a lead molecule, we successfully designed and synthesized a series of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents. One of the most potent compounds, 3b, inhibited the replication of various H3N2 and H1N1 influenza A virus strains with IC50 values ranging from 0.5 to 4.6 mu M. Compound 3b also strongly inhibited the replication of H5N1 (RG14), amantidine-resistant A/WSN/33 (H1N1), and oseltamivir-resistant A/WSN/1933 (H1N1, 274Y) virus strains with IC50 values in sub-mu M ranges. Further computational studies and mechanism investigation suggested that 3b might directly target influenza virus A nucleoprotein to inhibit its nuclear accumulation.

  DOI：

  10.1021/jm2013503

文献信息

• NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS
  申请人：Cianci Christopher W.

  公开号：US20120245176A1

  公开（公告）日：2012-09-27

  A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with —N, —O, or —S adjacent to the —Ar substituent or adjacent to the point of attachment for the —Ar substituent; Ar is aryl or heteroaryl; R is —CH 3 , —CH 2 F, —CHF 2 or —CH═CH 2 ; V is —H, —CH 3 or ═O; W is —NO 2 , —Cl, —Br, —CH 2 OH, or —CN; X is —Cl, —Br, —F, —CH 3 , —OCH 3 , or —CN; Y is —CH or —N; and Z is —CH or —N. This compound is useful in compositions for the prevention and treatment of influenza virus.

  本发明涉及一种I式化合物，包括其药学上可接受的盐：其中，Het是一种5或6元杂环，其中- N，-O或-S与-Ar取代基相邻或与-Ar取代基的连接点相邻；Ar是芳基或杂芳基；R是-CH3，-CH2F，-CHF2或-CH═CH2；V是-H，-CH3或═O；W是-NO2，-Cl，-Br，-CH2OH或-CN；X是-Cl，-Br，-F，-CH3，-OCH3或-CN；Y是-CH或-N；以及Z是-CH或-N。该化合物在预防和治疗流感病毒的组合物中有用。
• [EN] NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS<br/>[FR] NOUVEAUX ANALOGUES DE LA PIPÉRAZINE COMPORTANT DES GROUPES HÉTÉROARYLE SUBSTITUÉS UTILISÉS COMME ANTIVIRAUX À LARGE SPECTRE PROTÉGEANT DE LA GRIPPE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2012044531A8

  公开（公告）日：2012-08-09
• Design, Synthesis, and in Vitro Biological Evaluation of 1<i>H</i>-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein
  作者：Huimin Cheng、Junting Wan、Meng-I Lin、Yingxue Liu、Xiaoyun Lu、Jinsong Liu、Yong Xu、Jianxin Chen、Zhengchao Tu、Yih-Shyun E. Cheng、Ke Ding

  DOI：10.1021/jm2013503

  日期：2012.3.8

  The influenza virus nucleoprotein (NP) is an emerging target for anti-influenza drug development. Nucleozin (1) and its closely related derivatives had been identified as NP inhibitors displaying anti-influenza activity. Utilizing 1 as a lead molecule, we successfully designed and synthesized a series of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents. One of the most potent compounds, 3b, inhibited the replication of various H3N2 and H1N1 influenza A virus strains with IC50 values ranging from 0.5 to 4.6 mu M. Compound 3b also strongly inhibited the replication of H5N1 (RG14), amantidine-resistant A/WSN/33 (H1N1), and oseltamivir-resistant A/WSN/1933 (H1N1, 274Y) virus strains with IC50 values in sub-mu M ranges. Further computational studies and mechanism investigation suggested that 3b might directly target influenza virus A nucleoprotein to inhibit its nuclear accumulation.