[1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanol | 2059147-59-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanol
• 英文别名: 1H-Pyrazole-4-methanol, 1,5-dimethyl-3-(trifluoromethyl)-；[1,5-dimethyl-3-(trifluoromethyl)pyrazol-4-yl]methanol
• CAS: 2059147-59-8
• 化学式: C₇H₉F₃N₂O
• 分子量: 194.156
• InChiKey: YKJRYZDHSNNEAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanol 在 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 2-[1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]acetonitrile
  参考文献：
  名称：

  [EN] COMPOUNDS AND THEIR USE AS INHIBITORS OF N-MYRISTOYL TRANSFERASE
  [FR] COMPOSÉS ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA N-MYRISTOYL TRANSFÉRASE

  摘要：

  这项发明提供了式（I）的化合物及其盐，具有作为N-肉豆蔻酰转移酶（NMT）抑制剂的活性。该发明还涉及将这类化合物用作药物的用途，特别是在治疗需要抑制N-肉豆蔻酰转移酶以产生治疗或预防效果的疾病或紊乱中，包括原虫感染（如疟疾和利什曼病）、病毒感染（如人类鼻病毒和HIV）以及高增殖性疾病（如B细胞淋巴瘤）。

  公开号：

  WO2017001812A1
• 作为产物：
  描述：

  4-溴-1,5-二甲基-3-(三氟甲基)-1H-吡唑 在 甲醇 、 sodium tetrahydroborate 、 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 5.0h， 生成 [1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methanol
  参考文献：
  名称：

  [EN] COMPOUNDS AND THEIR USE AS INHIBITORS OF N-MYRISTOYL TRANSFERASE
  [FR] COMPOSÉS ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA N-MYRISTOYL TRANSFÉRASE

  摘要：

  这项发明提供了式（I）的化合物及其盐，具有作为N-肉豆蔻酰转移酶（NMT）抑制剂的活性。该发明还涉及将这类化合物用作药物的用途，特别是在治疗需要抑制N-肉豆蔻酰转移酶以产生治疗或预防效果的疾病或紊乱中，包括原虫感染（如疟疾和利什曼病）、病毒感染（如人类鼻病毒和HIV）以及高增殖性疾病（如B细胞淋巴瘤）。

  公开号：

  WO2017001812A1

文献信息

• Compounds and their use as inhibitors of N-myristoyl transferase
  申请人：Imperial College Innovations Limited

  公开号：US10759804B2

  公开（公告）日：2020-09-01

  This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

  本发明提供了式(I)化合物及其盐类，它们具有作为N-肉豆蔻酰转移酶(NMT)抑制剂的活性。本发明还涉及此类化合物作为药物的用途，特别是在治疗抑制 N-肉豆蔻酰基转移酶可提供治疗或预防效果的疾病或紊乱中的用途，包括原生动物感染（如疟疾和利什曼病）、病毒感染（如人类鼻病毒和 HIV）和过度增殖性紊乱（如 B 细胞淋巴瘤）。
• COMPOUNDS AND THEIR USE AS INHIBITORS OF N-MYRISTOYL TRANSFERASE
  申请人：Imperial College Innovations Limited

  公开号：EP3313833B1

  公开（公告）日：2021-01-06
• ORGANIC ELECTROLUMINESCENCE ELEMENT, LIGHTING DEVICE AND DISPLAY DEVICE
  申请人：Katakura Rie

  公开号：US20100045171A1

  公开（公告）日：2010-02-25

  Disclosed is an organic electroluminescent device having high external quantum efficiency and long emission life. Also disclosed are an illuminating device and a display, each comprising such an organic electroluminescent device. The organic electroluminescent device is characterized by comprising at least an anode and a cathode on a supporting substrate, while having at least one light-emitting layer between the anode and the cathode. The organic electroluminescent device is also characterized by containing a polymer which at least partially contains a compound A having a partial structure represented by the general formula (a) below and a reactive group, and is obtained by polymerizing the compound A through the reactive group. (In the formula, Ar1 and Ar2 respectively represent an aromatic ring.)
• Compounds And Their Use As Inhibitors Of N-Myristoyl Transferase
  申请人：Imperial Innovations Limited

  公开号：US20180370974A1

  公开（公告）日：2018-12-27

  This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).
• Novel compounds and their use in therapy
  申请人：Imperial College Innovations Limited

  公开号：US20220411431A1

  公开（公告）日：2022-12-29

  This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).