2-(Hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-yl dihydrogen phosphate | 25878-33-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-yl dihydrogen phosphate
• 英文别名: [4-(hydroxymethyl)-10-imino-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-5-yl] dihydrogen phosphate
• CAS: 25878-33-5
• 化学式: C₉H₁₂N₃O₇P
• 分子量: 305.18
• InChiKey: MHEIPMMGYDKOAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Inhibitors of Mcl-1 and Akt Binding, Pharmaceutical Compositions, and Uses in Treating Cancer
  申请人：Emory University

  公开号：US20210137953A1

  公开（公告）日：2021-05-13

  This disclosure relates to inhibitors of Mcl-1 and Akt binding, pharmaceutical compositions, and uses in treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of an inhibitor of Mcl-1 and Akt binding to a subject in need thereof. In certain embodiments, the inhibitor prevents the PEST domain of Mcl-1 from directly interacting with the pleckstrin homology (PH) domain of Akt.
• [EN] KINASE PROTEIN BINDING INHIBITORS<br/>[FR] INHIBITEURS DE LA LIAISON À UNE PROTÉINE KINASE
  申请人：UNIV FLORIDA

  公开号：WO2010104598A2

  公开（公告）日：2010-09-16

  The invention provides compounds capable of treating a subject suffering from or being susceptible to a cell proliferative disorder (especially, cancer), methods of identifying and using the compounds, pharmaceutical compositions and kits thereof.