2-[(Acenaphtho[1,2-b]quinolin-10-ylmethyl)amino]2-methyl-1,3-propanediol | 103997-15-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[(Acenaphtho[1,2-b]quinolin-10-ylmethyl)amino]2-methyl-1,3-propanediol
• 英文别名: 2-(Acenaphthyleno[2,1-b]quinolin-10-ylmethylamino)-2-methylpropane-1,3-diol
• CAS: 103997-15-5
• 化学式: C₂₄H₂₂N₂O₂
• 分子量: 370.451
• InChiKey: TYEOQTBPQDBHDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  65.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  acenaphtho[1,2-b]quinoline-10-carbaldehyde 、 2-氨基-2-甲基-1,3-丙二醇 以55%的产率得到
  参考文献：
  名称：

  BAIR, KENNETH W.

  摘要：

  DOI：

文献信息

• Certain substituted naphthofurans with anti-tumor properties
  申请人：Burroughs Wellcome Co.

  公开号：US05008286A1

  公开（公告）日：1991-04-16

  The present invention relates to compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acide addition salts thereof; wherein Ar is a fused tricyclic aromatic ring system containing a maximum of 14 ring atoms and at least one heteroatom or a fused pentacyclic ring system with at least 4 aromatic rings containing a maximum of 22 ring atoms and at least one heteroatom; or a substituted derivative thereof; for either the tricyclic or pentacyclic ring system there is a maximum of one heteroatom for each ring present but preferably only one or two of the rings contain a heteroatom; the rings forming the tricyclic or the pentacyclic ring system contain five or six atoms; the heteroatoms are conveniently nitrogen, phosphorus, oxygen, sulfur or selenium; suitably the heteroatom is oxygen, sulfur or nitrogen; the tricyclic or the pentacyclic ring system should be planar or deviate only slightly from planarity; suitably the ring system is aromatic or contains one non-aromatic ring; preferably the ring system is aromatic; nitrogen atoms contained in five-membered rings are substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl. The compounds have biocidal properties.

  本发明涉及化合物的公式（I）ArCH.sub.2 R.sup.1（I）或其单甲基或单乙基醚（公式（I）的化合物包括这些醚，总共不超过29个碳原子）；醚，酯；酸盐；其中Ar是含有最多14个环原子和至少一个杂原子的融合三环芳香环系统或至少4个芳香环的含有最多22个环原子和至少一个杂原子的融合五环系统；或其取代衍生物；对于三环或五环系统，每个环最多有一个杂原子，但最好只有一个或两个环含有杂原子；形成三环或五环系统的环包含五个或六个原子；杂原子方便地是氮、磷、氧、硫或硒；适宜的杂原子是氧、硫或氮；三环或五环系统应该是平面的或仅略微偏离平面；合适的环系统是芳香的或包含一个非芳香环；最好环系统是芳香的；五元环中含氮原子被氢、甲基或乙基取代；R.sup.1含有不超过八个碳原子，是一个基团##STR1##其中m为0或1；R.sup.5是氢；R.sup.6和R.sup.7相同或不同，每个是氢或C.sub.1-5烷基，可选择地被羟基取代；R.sup.8和R.sup.9相同或不同，每个是氢或C.sub.1-3烷基；##STR2##是一个五元或六元饱和碳环；R.sup.10是氢、甲基或羟甲基；R.sup.11、R.sup.12和R.sup.13相同或不同，每个是氢或甲基；R.sup.14是氢、甲基、羟基或羟甲基。这些化合物具有杀生物性能。
• Polycyclic compounds, their preparation and use and formulations containing them
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0183439B1

  公开（公告）日：1993-02-03
• BAIR, KENNETH W.
  作者：BAIR, KENNETH W.

  DOI：——

  日期：——
• US4866070A
  申请人：——

  公开号：US4866070A

  公开（公告）日：1989-09-12
• US4965285A
  申请人：——

  公开号：US4965285A

  公开（公告）日：1990-10-23