2-(6-methyl-2,3-dihydro-1H-quinolin-4-ylidene)propanedinitrile | 30197-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(6-methyl-2,3-dihydro-1H-quinolin-4-ylidene)propanedinitrile
• 英文别名: (6-Methyl-2,3-dihydroquinolin-4(1h)-ylidene)propanedinitrile
• CAS: 30197-76-3
• 化学式: C₁₃H₁₁N₃
• 分子量: 209.25
• InChiKey: FZPBQKLWMYXOJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  59.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• T5 exonuclease-based method to identify DNA topoisomerase inhibitors
  申请人：Leng Fenfei

  公开号：US11268129B1

  公开（公告）日：2022-03-08

  The present invention provides assays and methods for studying DNA topology and topoisomerases. The assays and methods utilize a circular plasmid DNA comprising one or more hairpin structures and the ability of T5 exonuclease (T5E) to digest the circular plasmid DNA in a specific configuration. The assays and methods can be used as a high throughput screening for inhibitors of, for example, DNA gyrases and DNA topoisomerases I for anticancer drug and antibiotics discovery.

  本发明提供了研究DNA拓扑结构和拓扑异构酶的检测方法。这些检测方法利用包含一个或多个发夹结构的环状质粒 DNA 以及 T5 外切酶（T5E）以特定构型消化环状质粒 DNA 的能力。这些检测方法可用于高通量筛选 DNA 回旋酶和 DNA 拓扑异构酶 I 等的抑制剂，以发现抗癌药物和抗生素。
• T5 EXONUCLEASE-BASED METHOD TO IDENTIFY DNA TOPOISOMERASE INHIBITORS
  申请人：LENG Fenfei

  公开号：US20220119858A1

  公开（公告）日：2022-04-21

  The present invention provides assays and methods for studying DNA topology and topoisomerases. The assays and methods utilize a circular plasmid DNA comprising one or more hairpin structures and the ability of T5 exonuclease (T5E) to digest the circular plasmid DNA in a specific configuration. The assays and methods can be used as a high throughput screening for inhibitors of, for example, DNA gyrases and DNA topoisomerases I for anticancer drug and antibiotics discovery.
• [EN] TARGETING MB2 OF THE MYC ONCOGENE AND ITS INTERACTION WITH TRRAP IN CANCER<br/>[FR] CIBLAGE DE MB2 DE L'ONCOGÈNE MYC ET SON INTERACTION AVEC TRRAP DANS LE CANCER
  申请人：DARTMOUTH COLLEGE

  公开号：WO2021113347A1

  公开（公告）日：2021-06-10

  Provided are methods and compositions for identifying inhibitors of an interaction between the oncogenic transcription factor MYC and its cofactor TRRAP. The methods involve both cell-based and in vitro approaches for probing an interaction between MYC and TRRAP and for identifying inhibitors of a MYC-TRRAP interaction. Also provided are compounds for use as inhibitors of an interaction between MYC and TRRAP, and methods for developing a cancer therapeutic from such compounds, including methods for derivatizing such inhibitors and for testing the inhibitors and derivatized inhibitors for an ability to treat cancer in a subject. The methods, compounds, and compositions provided herein can provide various advantages, such as a means to target the oncogenic transcription factor MYC in cancer.