(2S,3S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)thio>hept-6-en-2-ol | 139965-01-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (2S,3S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)thio>hept-6-en-2-ol
• 英文别名: (2S,3S)-1,1-dichloro-1-fluoro-3-(4-methylphenyl)sulfanylhept-6-en-2-ol
• CAS: 139965-01-8
• 化学式: C₁₄H₁₇Cl₂FOS
• 分子量: 323.259
• InChiKey: PPHHBBNAGYMBGD-STQMWFEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-(-)-2-苯基丙酸 、 (2S,3S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)thio>hept-6-en-2-ol 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 (R)-2-Phenyl-propionic acid (1S,2S)-1-(dichloro-fluoro-methyl)-2-p-tolylsulfanyl-hex-5-enyl ester
  参考文献：
  名称：

  Synthesis of Enantiomerically Pure Fluoro- and gem-Chlorofluorocyclohexane Derivatives

  摘要：

  gem-Chloronuorocyclohexanols 10 are prepared in good yields by radical-promoted cyclization from the corresponding omega-dichlorofluoroheptenols 4. Fluorocyclohexanols 11 are obtained either from 10 or in a single step from open-chain alcohols 4. The stereochemical outcome of both the radical cyclization and the reductive dechlorination is discussed. Elimination of the chiral auxiliary sulfinyl group and appropriate elaborations afford enantiomerically pure derivatives 12-17. Relative and absolute configurations as well as preferred conformations in solution for all final compounds are provided.

  DOI：

  10.1021/jo00100a057
• 作为产物：
  描述：

  (+)-(R_S)-5-<(4-Methylphenyl)sulfinyl>pent-1-ene 在 sodium tetrahydroborate 、 三氟乙酸酐 、 sodium iodide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 ammonium hydroxide 、 丙酮 为溶剂， 反应 0.42h， 生成 (2S,3S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)thio>hept-6-en-2-ol
  参考文献：
  名称：

  Synthesis of Enantiomerically Pure Fluoro- and gem-Chlorofluorocyclohexane Derivatives

  摘要：

  gem-Chloronuorocyclohexanols 10 are prepared in good yields by radical-promoted cyclization from the corresponding omega-dichlorofluoroheptenols 4. Fluorocyclohexanols 11 are obtained either from 10 or in a single step from open-chain alcohols 4. The stereochemical outcome of both the radical cyclization and the reductive dechlorination is discussed. Elimination of the chiral auxiliary sulfinyl group and appropriate elaborations afford enantiomerically pure derivatives 12-17. Relative and absolute configurations as well as preferred conformations in solution for all final compounds are provided.

  DOI：

  10.1021/jo00100a057

文献信息

• Synthesis of Enantiomerically Pure Fluoro- and gem-Chlorofluorocyclohexane Derivatives
  作者：Alberto Arnone、Pierfrancesco Bravo、Massimo Frigerio、Fiorenza Viani、Giancarlo Cavicchio、Marcello Crucianelli

  DOI：10.1021/jo00100a057

  日期：1994.10

  gem-Chloronuorocyclohexanols 10 are prepared in good yields by radical-promoted cyclization from the corresponding omega-dichlorofluoroheptenols 4. Fluorocyclohexanols 11 are obtained either from 10 or in a single step from open-chain alcohols 4. The stereochemical outcome of both the radical cyclization and the reductive dechlorination is discussed. Elimination of the chiral auxiliary sulfinyl group and appropriate elaborations afford enantiomerically pure derivatives 12-17. Relative and absolute configurations as well as preferred conformations in solution for all final compounds are provided.