(2-tert-butylpyridin-4-yl)-(3,4-dihydro-2H-quinolin-1-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2-tert-butylpyridin-4-yl)-(3,4-dihydro-2H-quinolin-1-yl)methanone
• 化学式: C₁₉H₂₂N₂O
• 分子量: 294.4
• InChiKey: HKUHLJOBUBAQPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• UREA DERIVATIVES AS INHIBITORS OF ASK1
  申请人：Hepagene Therapeutics, Inc.

  公开号：US20200339530A1

  公开（公告）日：2020-10-29

  The present technology is directed to compounds, compositions, and methods related to inhibition of ASK1. In particular, the present compounds (e.g., compounds of Formula I as defined herein) and compositions may be used to treat ASK1-mediated disorders and conditions, including, e.g., fibrotic diseases and acute and chronic liver diseases, among others.