3-(2-methyl-1H-indol-3-yl)-1,3-diphenylprop-2-en-1-one | 102665-32-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(2-methyl-1H-indol-3-yl)-1,3-diphenylprop-2-en-1-one
• CAS: 102665-32-7
• 化学式: C₂₄H₁₉NO
• 分子量: 337.421
• InChiKey: UQFHORIGEDYRLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基吲哚 、 二苯甲酰基甲烷 在 N,N,N′,N′-tetramethylguanidinium trifluoroacetate 作用下， 反应 0.42h， 以93%的产率得到3-(2-methyl-1H-indol-3-yl)-1,3-diphenylprop-2-en-1-one
  参考文献：
  名称：

  Indole 3-alkylation/vinylation under catalysis of the guanidinium ionic liquids

  摘要：

  Two ionic liquids, N,N,N,N-tetramethylguanidinium trifluoroacetate (TMGT) and the unprecedented N,N,N,N-tetramethylguanidinium triflate (TMCTf), were used as catalyst solvents in condensations between indoles and arylaldehydes or 1,3-diketones providing a simple and efficient method for synthesis of bis(3-indolyl)methanes or casually 3-alkenylindoles due to stereoelectronic concerns of reactants. The ionic liquids are easily separated and reused for several times. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.08.073

文献信息

• Indole 3-alkylation/vinylation under catalysis of the guanidinium ionic liquids
  作者：Kurosh Rad-Moghadam、Masoumeh Sharifi-Kiasaraie

  DOI：10.1016/j.tet.2009.08.073

  日期：2009.10

  Two ionic liquids, N,N,N,N-tetramethylguanidinium trifluoroacetate (TMGT) and the unprecedented N,N,N,N-tetramethylguanidinium triflate (TMCTf), were used as catalyst solvents in condensations between indoles and arylaldehydes or 1,3-diketones providing a simple and efficient method for synthesis of bis(3-indolyl)methanes or casually 3-alkenylindoles due to stereoelectronic concerns of reactants. The ionic liquids are easily separated and reused for several times. (c) 2009 Elsevier Ltd. All rights reserved.