prenyl isopropyl ether | 50340-55-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: prenyl isopropyl ether
• 英文别名: 1-isopropoxy-3-methyl-but-2-ene；4-Isopropyloxy-2-methyl-buten-(2)；1-Isopropoxy-3-methyl-but-2-en；2-Methyl-buten-(2)-ol-(4)-isopropylaether；3-Methyl-1-propan-2-yloxybut-2-ene
• CAS: 50340-55-1
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: VPSIBBZAIGTOME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  重氮乙酸乙酯 、 prenyl isopropyl ether 在 copper(II) sulfate 作用下， 以32.2%的产率得到ethyl 2-isopropoxymethyl-3,3-dimethylcyclopropane-1-carboxylate
  参考文献：
  名称：

  Balakireva, E.G.; Khaliullin, R.R.; Plemenkov, V.V., Russian Journal of Organic Chemistry, 1993, vol. 29, # 12.2, p. 2045 - 2046

  摘要：

  DOI：
• 作为产物：
  描述：

  异丙醇 、 1-氯-3-甲基-2-丁烯 在 sodium hydroxide 、 苄基三乙基氯化铵 作用下， 生成 prenyl isopropyl ether
  参考文献：
  名称：

  Balakireva, E.G.; Khaliullin, R.R.; Plemenkov, V.V., Russian Journal of Organic Chemistry, 1993, vol. 29, # 12.2, p. 2045 - 2046

  摘要：

  DOI：

文献信息

• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：SHY Therapeutics LLC

  公开号：US20170174699A1

  公开（公告）日：2017-06-22

  Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

  本文提供了抑制MAPK磷酸化的化合物，因此可用于治疗癌症和炎症性疾病的组合物和方法。
• Inhibitors of human immunodeficiency virus replication
  申请人：TSANTRIZOS Youla S.

  公开号：US20080221159A1

  公开（公告）日：2008-09-11

  Compounds of formula I: wherein a, b, c, X, R 2 , R 3 , R 4 , R 6 and R 7 are defined herein, are useful as inhibitors of HIV replication.

  式I的化合物：其中a、b、c、X、R2、R3、R4、R6和R7如此定义，对于抑制HIV复制是有用的。
• Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
  申请人：Shy Therapeutics LLC

  公开号：US11213515B1

  公开（公告）日：2022-01-04

  Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

  本文提供了通过化合物与 Ras 超家族蛋白（在某些情况下包括 K-Ras 及其突变体）的 GTP 结合结构域结合，治疗涉及 Ras 超家族信号异常的癌症、炎症性疾病、rasopathies 和纤维化疾病的方法和组合物，以及检测此类组合物的新方法。
• PROBES FOR RAPID AND SPECIFIC DETECTION OF MYCOBACTERIA
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20170044593A1

  公开（公告）日：2017-02-16

  The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam-antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a β-lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.
• US7939545B2
  申请人：——

  公开号：US7939545B2

  公开（公告）日：2011-05-10