2-tert-butyl-3-propylbenzo[h]quinoline | 1210435-68-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-tert-butyl-3-propylbenzo[h]quinoline
• 英文别名: 2-Tert-butyl-3-propylbenzo[h]quinoline
• CAS: 1210435-68-9
• 化学式: C₂₀H₂₃N
• 分子量: 277.409
• InChiKey: TWURJLKTAZHXHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-N-naphthalen-1-ylpropionimidoyl chloride 、 alkaline earth salt of/the/ methylsulfuric acid 在 三乙胺 、 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 0.25h， 以51%的产率得到2-tert-butyl-3-propylbenzo[h]quinoline
  参考文献：
  名称：

  Different Reactivities of Alkoxy- and Thiocarbene Complexes of Fischer-Type: Formation of (N-Enamino)ethoxycarbene Complexes and Quinolines, Respectively

  摘要：

  Alkoxy- and thiocarbene complexes of chromium and tungsten afford different type of products on reaction with (N-aryl)imidoyl chlorides. The (n-butyl)ethoxycarbene complex [(OC)(5)W=C(OEt)n-Bu] and (N-aryl)imidoyl chlorides t-BuClC=NC(6)H(4)R(4) (R(4) = H, OMe) undergo a rearrangement to (N-enamino)ethoxycarbene complexes, whereas quinolines are obtained from the corresponding reaction of (alkyl)thiocarbene complexes [(OC)(5)M=C(SEt)CH(2)R] (M = W, Cr; R = n-Pr, Me) with (N-aryl)imidoyl chlorides R(1)ClC=NC(6)H(2)R(2)R(3)R(4) (R(1) = t-Bu, Ph; R(2), R(3) = H, HC=CH-CH=CH; R(4) = H, OMe, Me) by beta-cyclization.

  DOI：

  10.1021/om900807s

文献信息

• Different Reactivities of Alkoxy- and Thiocarbene Complexes of Fischer-Type: Formation of (<i>N</i>-Enamino)ethoxycarbene Complexes and Quinolines, Respectively
  作者：Betül Karataş、Rudolf Aumann

  DOI：10.1021/om900807s

  日期：2010.2.22

  Alkoxy- and thiocarbene complexes of chromium and tungsten afford different type of products on reaction with (N-aryl)imidoyl chlorides. The (n-butyl)ethoxycarbene complex [(OC)(5)W=C(OEt)n-Bu] and (N-aryl)imidoyl chlorides t-BuClC=NC(6)H(4)R(4) (R(4) = H, OMe) undergo a rearrangement to (N-enamino)ethoxycarbene complexes, whereas quinolines are obtained from the corresponding reaction of (alkyl)thiocarbene complexes [(OC)(5)M=C(SEt)CH(2)R] (M = W, Cr; R = n-Pr, Me) with (N-aryl)imidoyl chlorides R(1)ClC=NC(6)H(2)R(2)R(3)R(4) (R(1) = t-Bu, Ph; R(2), R(3) = H, HC=CH-CH=CH; R(4) = H, OMe, Me) by beta-cyclization.