4-Hydroxy-6-oxo-2-phenyl-cyclohex-4-ene-1,3-dicarboxylic acid diethyl ester | 144284-94-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Hydroxy-6-oxo-2-phenyl-cyclohex-4-ene-1,3-dicarboxylic acid diethyl ester
• 英文别名: Diethyl 4-hydroxy-6-oxo-2-phenylcyclohex-4-ene-1,3-dicarboxylate
• CAS: 144284-94-6
• 化学式: C₁₈H₂₀O₆
• 分子量: 332.353
• InChiKey: KPQCMDPVYPVFLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-6-oxo-2-phenyl-cyclohex-4-ene-1,3-dicarboxylic acid diethyl ester 、 N-(4-二甲氨基苄亚基)苯胺 以 乙醇 为溶剂， 生成 diethyl 5-[[3,5-bis(ethoxycarbonyl)-2,6-dioxo-4-phenylcyclohexyl]-[4-(dimethylamino)phenyl]methyl]-4,6-dioxo-2-phenylcyclohexane-1,3-dicarboxylate
  参考文献：
  名称：

  New aspects in the reaction of azomethines with cyclic CH-acidic compounds

  摘要：

  Treatment of substituted benzylidene anilines 1 a - f with cyclic CH-acidic compounds 2 a - m in ethanol at room temperature yields in additon/elimination reactions the corresponding arylidene derivatives 4 and the 2 : 1 adducts 5. The addition products 3, which are formed as intermediates, could not be isolated in any case. The donor/acceptor effect of the substituents on the benzylidene moiety influences to a significant extent the reactivity towards the azomethine carbon.

  DOI：

  10.1007/bf00816851

文献信息

• New aspects in the reaction of azomethines with cyclic CH-acidic compounds
  作者：Lothar Hennig、Mario Alva-Astudillo、Gerhard Mann、Thomas Kappe

  DOI：10.1007/bf00816851

  日期：——

  Treatment of substituted benzylidene anilines 1 a - f with cyclic CH-acidic compounds 2 a - m in ethanol at room temperature yields in additon/elimination reactions the corresponding arylidene derivatives 4 and the 2 : 1 adducts 5. The addition products 3, which are formed as intermediates, could not be isolated in any case. The donor/acceptor effect of the substituents on the benzylidene moiety influences to a significant extent the reactivity towards the azomethine carbon.