N-(4-丙氧基苯基)乙酰胺 | 20367-32-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-丙氧基苯基)乙酰胺
• 英文名称: 4-propoxyacetanilide
• 英文别名: acetic acid-(4-propoxy-anilide)；4-Acetamino-phenol-propylaether；Essigsaeure-(4-propoxy-anilid)；N-(4-propoxyphenyl)acetamide；4-Propoxyacetanilid
• CAS: 20367-32-2
• 化学式: C₁₁H₁₅NO₂
• mdl: MFCD00460750
• 分子量: 193.246
• InChiKey: WDRXFPOGKSGHFM-UHFFFAOYSA-N

物化性质

• 溶解度：
  8.80e-04 M

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-(4-丙氧基苯基)乙酰胺 在 溶剂黄146 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Synthesis and mesomorphic properties of 2,4-bis(4′-n-pentyloxybenzoyloxy)- benzylidine-4″- n-alkoxyaniline

  摘要：

  The synthesis andmesomorphic properties of a new series of 2,4-bis(4'-n-pentyloxybenzoyloxy)- benzylidine-4 ''-n-alkoxyaniline (DC5An) are reported. The molecular structure of compounds was confirmed by FTIR, H-1-NMR, C-13-NMR, mass spectroscopy and elemental analysis. The mesomorphic properties were studied by differential scanning calorimetry (DSC) and polarizing optical microscopy (POM) measurements. All compounds of the series exhibit nematic (N) and smectic C (SmC) phases. The first four homologues (DC5A1-DC5A4) display a N mesophase, whereas the highest homologues (DC5A5-DC5A10) exhibit an enantiotropic dimorphism N and SmC phases. The mesomorphic properties of the present series are compared and discussed with other structurally related series.

  DOI：

  10.1080/15421406.2017.1357426
• 作为产物：
  描述：

  对乙酰氨基酚 、 1-碘代丙烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以93%的产率得到N-(4-丙氧基苯基)乙酰胺
  参考文献：
  名称：

  扑热息痛的功能化烷氧基芳烃重氮盐†

  摘要：

  芳族乙酰胺四氟硼酸酯可以由芳族乙酰胺经一系列的脱乙酰基，重氮化和沉淀（由阴离子交换诱导）合成。该反应以方便的一瓶转化进行，并连续添加适当的试剂。不需要在分离产物之前交换溶剂或除去副产物。通过简单的过滤从反应混合物中分离出芳烃重氮盐。提出了两种互补的方案，并举例说明了该反应用于合成二芳基庚烷天然产物去-O-甲基中心洛宾的方法。

  DOI：

  10.1039/b924619c

文献信息

• [EN] HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANTIVIRAL DRUGS<br/>[FR] DÉRIVÉS D'HYDANTOÏNE ET DE THIOHYDANTOÏNE UTILISÉS COMME MÉDICAMENTS ANTIVIRAUX
  申请人：VIVALIS

  公开号：WO2013171281A1

  公开（公告）日：2013-11-21

  The present invention relates to a compound of the following formula (I), or a salt, solvate, tautomer, enantiomer, diastereoisomer or racemic mixture thereof: as well as its use as a drug, notably in the treatment of hepatitis C, its preparation process, and the pharmaceutical compositions containing such a compound.

  本发明涉及以下式（I）的化合物，或其盐、溶剂合物、互变异构体、对映异构体、顺反异构体或混合物，以及其作为药物的用途，特别是在治疗丙型肝炎方面的用途，其制备过程以及含有这种化合物的药物组合物。
• Role of Terminal Heterocyclic Ring on Mesomorphic Properties of Homologous Series*
  作者：B. T. Thaker、B. S. Patel、D. B. Solanki、Y. T. Dhimmer、J. S. Dave

  DOI：10.1080/15421400903290501

  日期：2010.2.25

  new homologous series of compounds with a heterocyclic ring having sulfur and oxygen as a hetero atom derived from p-hydroxy acetophenone and alkoxy aniline containing cinnamate-azomethine as central linkages have been synthesized. viz. 4(furalacryloxy) α-methyl benzylidine-4′-alkoxy aniline and 4(thianylacryloxy) α-methyl benzylidine-4′-alkoxy aniline. The compound of both the series have been characterized

  以对羟基苯乙酮和含有肉桂酸酯-偶氮甲碱为中心键的烷氧基苯胺衍生的以硫和氧为杂原子的杂环合成了两个新的同源系列化合物。即。4(furalacryloxy) α-methyl benzylidine-4'-alkoxy aniline 和 4(thianylacryloxy) α-methyl benzylidine-4'-alkoxy aniline。这两个系列的化合物均已通过元素分析、FT-IR、1H-NMR和质谱法表征。已经通过光学偏光显微镜和差示扫描量热法 (DSC) 研究研究了它们的液晶特性。所有衍生物本质上都是介晶的，显示出向列相。
• Efficient synthesis of anthranilic esters via Pd-catalyzed dehydrogenative/decarbonylative coupling of anilides and glyoxylates
  作者：Sizhuo Wang、Zhiyong Yang、Jidan Liu、Kai Xie、Anwei Wang、Xiang Chen、Ze Tan

  DOI：10.1039/c2cc34473d

  日期：——

  A novel way of synthesizing anthranilic esters was developed via Pd-catalyzed dehydrogenative/decarbonylative coupling between anilides and glyoxylates.

  开发了一种通过Pd催化的脱氢/脱羟基耦合，将苯胺和乙醇酸酯合成邻氨基苯甲酸酯的新方法。
• NITRIC OXIDE RELEASING DERIVATIVES OF PARACETAMOL
  申请人：BHARDWAJ Tilak Raj

  公开号：US20100234472A1

  公开（公告）日：2010-09-16

  The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the corresponding nitrate ester derivatives. The nitrate esters of paracetamol are useful as analgesic, anti-inflammatory agents.

  本发明特别涉及对乙酰氨基酚的新型硝酸酯。通过将对乙酰氨基酚与二卤代烷基化合物反应，然后再与硝酸银反应，制备得到相应的硝酸酯衍生物。对乙酰氨基酚的硝酸酯在镇痛、抗炎方面有用。
• HEPATOPROTECTANT ACETAMINOPHEN MUTUAL PRODRUGS
  申请人：Muhammad Naweed

  公开号：US20110263545A1

  公开（公告）日：2011-10-27

  The present invention provides hepatoprotectant acetaminophen mutual prodrugs, which have an acetaminophen moiety covalently linked to a second moiety that may act as a hepatoprotectant against acetaminophen hepatotoxicity. Additionally, acetaminophen mutual prodrugs may have improved water solubility which may provide better suitability for parenteral and other dosage forms relative to administration of acetaminophen. Also provided are methods of treating a disease or condition that is responsive to acetaminophen (such as fever, pain and ischemic injury) using hepatoprotectant acetaminophen mutual prodrugs, as well as kits and unit dosages.

  本发明提供了肝保护醋氨酚共价偶联物，其含有醋氨酚基团与第二基团共价结合，第二基团可能作为肝保护剂对抗醋氨酚肝毒性。此外，醋氨酚共价偶联物可能具有改善的水溶性，相对于醋氨酚的给药方式，更适合于静脉和其他剂型的使用。本发明还提供了使用肝保护醋氨酚共价偶联物治疗对醋氨酚具有反应的疾病或病况的方法（如发热、疼痛和缺血性损伤），以及套装和单元剂量。