1-aminopyrrolo[1,2-a]quinoline-2-carbonitrile | 1016230-66-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-aminopyrrolo[1,2-a]quinoline-2-carbonitrile
• 英文别名: 1-Aminopyrrolo[1,2-a]quinoline-2-carbonitrile
• CAS: 1016230-66-2
• 化学式: C₁₃H₉N₃
• 分子量: 207.235
• InChiKey: SSDZWGUUZLMERQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(quinolin-2-ylmethylene)malononitrile 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 0.17h， 以0.865 g的产率得到1-aminopyrrolo[1,2-a]quinoline-2-carbonitrile
  参考文献：
  名称：

  单取代丙二腈：丙二腈与芳香醛的高效一锅还原烷基化反应

  摘要：

  已经开发了一种强大的新一锅法，用于丙二腈与芳香醛的还原烷基化。这种新工艺极大地提高了工艺的产率和效率，并扩大了芳香醛的范围。在缩合步骤的乙醇中加入水作为催化剂允许使用化学计量的丙二腈和醛。还原步骤用硼氢化钠快速有效地进行，通过过滤或萃取得到单取代的丙二腈。2-喹啉甲醛的产物迅速重排为新的中氮茚，而单取代衍生物的烷基化提供了不重排的不对称二取代丙二腈。

  DOI：

  10.1055/s-2007-990945

文献信息

• One-pot multistep synthesis of 3-aminoindolizine derivatives
  作者：Lianhai Li、Waepril Kimberly S. Chua

  DOI：10.1016/j.tetlet.2011.01.087

  日期：2011.3

  We have developed an efficient one-pot multistep sequence to the synthesis of 3-aminoindolizine derivatives by using Hantzsch ester (9) as a mild hydride transfer agent. The reaction scope was investigated and the effect of substrates on reaction outcomes was discussed. (C) 2011 Published by Elsevier Ltd.
• OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST
  申请人：L'OREAL

  公开号：US20160136077A1

  公开（公告）日：2016-05-19

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and of a composition (A) comprising: —one or more oxidizing agents, and —at least one aminobenzimidazole oxidation base of formula (I) in which the radicals R1 to R5 represent, independently of each other, a hydrogen atom; a halogen atom; a C1-C6 alkyl radical; a C1-C6 alkoxy radical; a C1-C6 dialkylamino radical; a carboxylic radical (—COOH); a sulfonic radical (—S03H); a phenyl radical; a sat orated or unsaturated 5- to 7-membered heterocyclic radical, comprising one or more heteroatoms chosen from N, O and S.
• [EN] OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST<br/>[FR] PROCÉDÉ DE COLORATION PAR OXYDATION À L'AIDE D'UNE COMPOSITION COMPRENANT UNE BASE D'OXYDATION AMINOBENZIMIDAZOLONE ET UN CATALYSEUR MÉTALLIQUE
  申请人：OREAL

  公开号：WO2014202792A2

  公开（公告）日：2014-12-24

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and of a composition (A) comprising : - one or more oxidizing agents, and - at least one aminobenzimidazole oxidation base of formula (I) in which the radicals R1 to R5 represent, independently of each other, a hydrogen atom; a halogen atom; a C1-C6 alkyl radical; a C1-C6 alkoxy radical; a C1-C6 dialkylamino radical; a carboxylic radical (- COOH); a sulfonic radical (-S03H); a phenyl radical; a saturated or unsaturated 5- to 7-membered heterocyclic radical, comprising one or more heteroatoms chosen from N, O and S.