5-(aminomethyl)-6-quinolinol dihydochloride | 84174-50-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(aminomethyl)-6-quinolinol dihydochloride
• 英文别名: 5-(Aminomethyl)quinolin-6-ol;hydrochloride
• CAS: 84174-50-5
• 化学式: C₁₀H₁₀N₂O*2ClH
• 分子量: 247.124
• InChiKey: UFNOWHLGKJLFBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.82
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  59.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-羟基喹啉 在 盐酸 、 硫酸 作用下， 以 乙醇 为溶剂， 反应 20.0h， 生成 5-(aminomethyl)-6-quinolinol dihydochloride
  参考文献：
  名称：

  2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogs

  摘要：

  A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydrochloride (2) and 7-(aminomethyl)-6-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalene hydrochloride (6) displayed a high order of activity.

  DOI：

  10.1021/jm00358a023

文献信息

• 2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogs
  作者：A. A. Deana、G. E. Stokker、E. M. Schultz、R. L. Smith、E. J. Cragoe、H. F. Russo、L. S. Watson

  DOI：10.1021/jm00358a023

  日期：1983.4

  A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydrochloride (2) and 7-(aminomethyl)-6-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalene hydrochloride (6) displayed a high order of activity.