ethyl ((1S)-5-{2-[2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)acetate | 496063-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl ((1S)-5-{2-[2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)acetate
• 英文别名: (1S)-(5-{2-[2-(4-bromo-phenyl)-5-methyl-oxazole-4-yl]-ethoxy}-indan-1-yl)-acetic acid ethyl ester；ethyl 2-[(1S)-5-[2-[2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2,3-dihydro-1H-inden-1-yl]acetate
• CAS: 496063-18-4
• 化学式: C₂₅H₂₆BrNO₄
• 分子量: 484.39
• InChiKey: FYYKMWANKNDZCK-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  61.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl ((1S)-5-{2-[2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)acetate 、 5-乙酰基-2-噻吩硼酸 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 、 甲苯 为溶剂， 反应 16.0h， 以46%的产率得到ethyl [(1S)-5-(2-{2-[4'-(5-acetyl-2-thienyl)-1,1'-biphenyl-4-yl]-5-methyl-1,3-oxazol-4-yl}ethoxy)-2,3-dihydro-1H-inden-1-yl]acetate
  参考文献：
  名称：

  METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES

  摘要：

  本发明提供了茚乙酸及其衍生物，以及用于治疗和/或预防认知障碍的方法。

  公开号：

  US20180153860A1

文献信息

• METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE
  申请人：T3D Therapeutics, Inc.

  公开号：US20180153859A1

  公开（公告）日：2018-06-07

  The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.

  本发明提供了关于人类主体的ApoE4基因型的吲哌乙酸及其衍生物的治疗和/或预防认知障碍的方法。
• Indane acetic acid derivatives and their use as pharmaceutical agents
  申请人：Wickens Philip

  公开号：US20050107392A1

  公开（公告）日：2005-05-19

  This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases and to pharmaceutical compositions containing these compounds.

  本发明涉及新型茚基乙酸衍生物，其在治疗糖尿病、肥胖症、高脂血症和动脉粥样硬化等疾病方面有用，并涉及含有这些化合物的制药组合物。
• Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
  申请人：——

  公开号：US20030216391A1

  公开（公告）日：2003-11-20

  This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

  本发明涉及新型茚烷乙酸衍生物，其在糖尿病、肥胖症、高脂血症和动脉粥样硬化等疾病的治疗中有用。本发明还涉及制备茚烷乙酸衍生物的中间体以及制备方法。
• Indane Acetic Acid Derivatives and Their Use as Pharmaceutical Agents, Intermediates, and Method of Preparation
  申请人：Lowe Derek B.

  公开号：US20090047687A1

  公开（公告）日：2009-02-19

  This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

  本发明涉及一种新型的茚环乙酸衍生物，其在治疗糖尿病、肥胖症、高脂血症和动脉粥样硬化等疾病方面具有用途。本发明还涉及在制备茚环乙酸衍生物时有用的中间体和制备方法。
• INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION
  申请人：Lowe Derek B.

  公开号：US20110065129A1

  公开（公告）日：2011-03-17

  This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

  本发明涉及新型茚烷乙酸衍生物，其在治疗糖尿病、肥胖症、高脂血症和动脉粥样硬化等疾病方面具有用途。该发明还涉及在制备茚烷乙酸衍生物的中间体以及制备方法方面有用的中间体。