The present application provides for a compound of Formula I or II:
or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.
[EN] RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE<br/>[FR] ANTAGONISTE DE RORγ ET SON UTILISATION EN MÉDECINE
申请人:SUNSHINE LAKE PHARMA CO LTD
公开号:WO2020011147A1
公开(公告)日:2020-01-16
Provided herein are compounds as RORγ antagonist having Formula (I). The compounds or pharmaceutical composition thereof can be used for regulating Retinoid-related orphan receptor gamma t (RORγt). Also provided herein are methods of preparation of the compounds and composition thereof, and uses thereof in treating or preventing RORγt mediated inflammation or autoimmune diseases in mammals, particularly humans.
Simple, Rapid Procedure for the Synthesis of Chloromethyl Methyl Ether and Other Chloro Alkyl Ethers<sup>1</sup>
作者:Martin A. Berliner、Katherine Belecki
DOI:10.1021/jo051344g
日期:2005.11.1
Zinc(II) salts catalyze the reaction between acetals and acid halides to provide haloalkyl ethers in near-quantitative yield. Reactions from millimole to mole scale are typically complete in 1−4 h with 0.01 mol % catalyst. The solutions of haloalkyl ethers thus obtained can be utilized directly in reactions in which the presence of the ester byproduct does not interfere. Excess haloalkyl ether is destroyed
Carbon Homologation of 1-Alkynes Using Alkoxymethyl Esters Mediated by Dichlorobis(trifluoromethanesulfonato)titanium(IV)
作者:Yoo Tanabe
DOI:10.1246/bcsj.67.3309
日期:1994.12
Various 1-alkynes were converted to 1-alkoxy-3-chloro-2-alkenes using alkoxymethyl esters and dichlorobis(trifluoromethanesulfonato)titanium(IV) [TiCl2(OTf)2, titanium(IV) bis(triflate)]. This carbon homologation proceeded in the case of not only simple 1-alkynes but also for several 3- or 4-dimethylcarbamoyloxy-, 5-benzoyloxy-, 5-phenoxycarbonyloxy-, and 5-methoxycarbonyloxy-1-alkynes. Among them
BiCl<sub>3</sub>-Facilitated removal of methoxymethyl-ether/ester derivatives and DFT study of –O–C–O– bond cleavage
作者:Angela Pacherille、Beza Tuga、Dhanashree Hallooman、Isaac Dos Reis、Mélodie Vermette、Bilkiss B. Issack、Lydia Rhyman、Ponnadurai Ramasami、Rajesh Sunasee
DOI:10.1039/d1nj00449b
日期:——
simple method for the cleavage of methoxymethyl (MOM)-ether and ester derivatives using bismuth trichloride (BiCl3) is described. The alkyl, alkenyl, alkynyl, benzyl and anthracene MOM ether derivatives, as well as MOM esters of both aliphatic and aromatic carboxylic acids, were deprotected in good yields. To better understand the molecular roles of BiCl3 and water for MOM cleavage, two possible binding