The invention is drawn to a universal method for preparing DNA samples for genotyping of single nucleotide polymorphisms (SNP), deletions and insertions by mass spectrometry. The invention relates to a method for genotyping that comprises three steps: a) reducing the complexity of the genome, b) generating allele specific products, c) analyzing the products by mass spectrometry, without purifying the products obtained in step b).
本发明涉及一种制备 DNA 样品的通用方法,用于通过质谱分析法对单核苷酸多态性 (SNP)、缺失和插入进行
基因分型。本发明涉及一种
基因分型方法,该方法包括三个步骤:a) 降低
基因组的复杂性;b) 生成等位
基因特异性产物;c) 通过质谱分析这些产物,而不纯化在步骤 b) 中获得的产物。