苯甲醇,3-甲氧基-a-丙基- | 1678-03-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 苯甲醇,3-甲氧基-a-丙基-
• 英文名称: 1-(3-methoxyphenyl)butan-1-ol
• 英文别名: 1-(3-methoxyphenyl)butanol；1-(3-Methoxyphenyl)-1-butanol；α-Oxy-α-(3-methoxy-phenyl)-butan；1¹-Oxy-3-methoxy-1-butyl-benzol；α-(3-Methoxy-phenyl)-butylalkohol；Propyl-(3-methoxy-phenyl)-carbinol
• CAS: 1678-03-1
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: VRLWWGJERFQPOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯甲醇,3-甲氧基-a-丙基- 在 吡啶 、 氯化亚砜 作用下， 以 二甲基亚砜 为溶剂， 生成 2-<2-Chlor-aethyl>-2-<3-methoxy-phenyl>-pentansaeure-nitril
  参考文献：
  名称：

  基于吡咯烷环的止痛药。IV。

  摘要：

  DOI：

  10.1021/jm00327a009
• 作为产物：
  描述：

  1-(3-Methoxy-2-trimethylsilanyl-phenyl)-butan-1-ol 在 copper(l) iodide 、 lithium tert-butoxide 、 3-氯-2-甲基丙烯 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以74%的产率得到苯甲醇,3-甲氧基-a-丙基-
  参考文献：
  名称：

  Copper(I) tert-butoxide-promoted coupling of o-(1-hydroxyalkyl)arylsilanes with organic halides

  摘要：

  Copper(l) tert-butoxide-promoted coupling of arylsilanes possessing a 1-hydroxyalkyl group at the o-position with organic halides proceeded to give disubstituted arenes. The results indicate that an intermediary arylcopper species is formed by aromatic Csp(2)-to-O silyl migration. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.094

文献信息

• 6-Membered heterocyclic compound and use thereof
  申请人：Shoda Motoshi

  公开号：US20070060590A1

  公开（公告）日：2007-03-15

  A compound represented by the general formula (I) or a salt thereof: [T represents oxygen atom and the like; V represents CH 2 and the like; R O1 to R O4 represent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents —CH(OH)— group and the like; and W represent —U 1 —(R W1 )(R W2 )—U 2 —U 3 group (U 1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; R W1 and R W2 represent hydrogen atom and the like; U 2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and U 3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.

  由通用公式(I)表示的化合物或其盐： [T代表氧原子等；V代表CH2等；RO1至RO4代表氢原子等；A代表具有2至8个碳原子的线型亚烷基或线型亚烯基等；D代表羧基等；X代表亚乙基、亚丙基等；E代表—CH(OH)—基团等；W代表—U1—(RW1)(RW2)—U2—U3基团（U1代表单键、具有1至4个碳原子的亚烷基等；RW1和RW2代表氢原子等；U2代表单键、具有1至4个碳原子的亚烷基等；U3代表具有1至8个碳原子的烷基等），或碳环或杂环化合物的残基]，其可作为预防性和/或治疗性药物的有效成分，用于治疗骨骼疾病如骨质疏松症和骨折、青光眼、溃疡性结肠炎等。
• Novel di-(3'-hydroxyphenyl)-alkane compounds, process of preparation and
  申请人：Klinge Pharma GmbH

  公开号：US04094994A1

  公开（公告）日：1978-06-13

  Compounds of di-(3'-hydroxyphenyl)-alkanes and their methyl ethers, of the formula ##STR1## wherein R is alkyl and R' is H or methyl, have activity against hormone-dependent breast carcinoma.

  二-(3'-羟基苯基)-烷烃及其甲醚化合物，化学式为##STR1##其中R为烷基，R'为H或甲基，对激素依赖性乳腺癌具有活性。
• Tandem α-Alkylation/Asymmetric Transfer Hydrogenation of Acetophenones with Primary Alcohols
  作者：Oleksandr O. Kovalenko、Helena Lundberg、Dennis Hübner、Hans Adolfsson

  DOI：10.1002/ejoc.201403032

  日期：2014.10

  A tandem -alkylation/asymmetric transfer hydrogenation of acetophenones with primary alcohols, mediated by a single ruthenium catalyst, is described. Under optimized reaction conditions and with use of [Ru(p-cymene)Cl-2](2) in combination with an amino acid hydroxyamide ligand, the chiral secondary alcohol products were isolated in moderate yields and in moderate to good enantiomeric excess (up to

  描述了由单一钌催化剂介导的苯乙酮与伯醇的串联烷基化/不对称转移氢化。在优化的反应条件下，并使用 [Ru(p-cymene)Cl-2](2) 与氨基酸羟基酰胺配体的组合，手性仲醇产物以中等收率和中等至良好的对映体过量（高达到 89% ee）。
• Halogen-bonded iodonium ion catalysis: a route to α-hydroxy ketones via domino oxidations of secondary alcohols and aliphatic C–H bonds with high selectivity and control
  作者：Somraj Guha、Imran Kazi、Pranamita Mukherjee、Govindasamy Sekar

  DOI：10.1039/c7cc05697d

  日期：——

  been developed from benzylic secondary alcohols employing catalytic iodonium ions stabilized by DMSO. The reaction proceeds through an unprecedented sequential oxidation of alcohols to ketone and its α-hydroxylation in a controlled manner. The spectroscopic evidences establish the possibility of formation of a stable halogen–bonded adduct between DMSO and iodonium ions.

  由苄基仲醇开发了α-羟基酮的多米诺合成，该苄基仲醇采用了由DMSO稳定的催化碘鎓离子。该反应通过将醇以前所未有的顺序氧化成酮并以受控方式进行其α-羟基化而进行。光谱学证据确定了在DMSO和碘鎓离子之间形成稳定的卤素键合加合物的可能性。
• Copper-catalyzed multiple oxidation and cycloaddition of aryl–alkyl ketones (alcohols) for the synthesis of 4-acyl- and 4-diketo-1,2,3-triazoles
  作者：Liangfeng Huang、Lei Zheng、Zhongzhen Zhou、Yunfeng Chen

  DOI：10.1039/d1cc06477k

  日期：——

  from readily-available aryl–alkyl ketones (or alcohols) and different organic azides. Moreover, the reaction used environmentally friendly dimethyl carbonate (DMC) as the solvent and air as the oxidant, and H2O was the only by-product, so it provides a green and practical synthetic method for 1,2,3-triazoles.

  已经开发了一种 Cu/TEMPO 催化的串联多重氧化脱氢和环加成反应，它可以从容易获得的芳基-烷基酮中得到 4-酰基-1,2,3-三唑和 4-二酮-1,2,3-三唑（或醇）和不同的有机叠氮化物。此外，该反应以环境友好的碳酸二甲酯（DMC）为溶剂，空气为氧化剂，副产物为H 2 O，为1,2,3-三唑类化合物的合成提供了一种绿色实用的方法。