4-(3,5-bis(trifluoromethyl)phenyl)-1-methyl-1H-pyrazole | 1610802-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(3,5-bis(trifluoromethyl)phenyl)-1-methyl-1H-pyrazole
• 英文别名: 4-[3,5-Bis(trifluoromethyl)phenyl]-1-methylpyrazole
• CAS: 1610802-76-0
• 化学式: C₁₂H₈F₆N₂
• 分子量: 294.199
• InChiKey: RPRQAADWTYLWSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-甲基-4-碘-吡唑 、 3,5-双(三氟甲基)苯硼酸 在 四(三苯基膦)钯 、 caesium carbonate 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 0.13h， 以86%的产率得到4-(3,5-bis(trifluoromethyl)phenyl)-1-methyl-1H-pyrazole
  参考文献：
  名称：

  Efficient synthesis of 4-substituted pyrazole via microwave-promoted Suzuki cross-coupling reaction

  摘要：

  Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive compounds. In contrast to 3 or 5-aryl pyrazole, the preparation of 4-aryl pyrazole is fairly rare. Utilizing microwave irradiation, the synthesis of 4-substituted-arylpyrazole via Suzuki cross-coupling has been developed with a wide range of substrates. The remarkable advantages of this method are mild reaction conditions, simple operation, high yield, and short reaction time. Product structures were identified by MS, H-1 NMR, C-13 NMR, and elemental analysis. (C) 2014 Qiong-You Wu and Guang-Fu Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2014.03.013

文献信息

• Alkinyl-Oxypyrimidines Used in the Form of Pesticides
  申请人：Bretschneider Thomas

  公开号：US20090005403A1

  公开（公告）日：2009-01-01

  The invention relates to compounds of the formula (I), in which A, R 1 , R 2 , R 3 and R 4 are as defined in the description, to processes and intermediates for their preparation and to their use for controlling pests.