3-tert-Butyl-5--pyrazol | 94033-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-tert-Butyl-5--pyrazol
• 英文别名: 3-tert-butyl-5-furan-2-yl-1(2)H-pyrazole；5-tert-butyl-3-(furan-2-yl)-1H-pyrazole
• CAS: 94033-10-0
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: VZUDOPGHOOZGNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(α-Furyl)-3-tert.-butyl-1-propen-3-on 在 sulfur 、 一水合肼 作用下， 反应 2.0h， 生成 3-tert-Butyl-5--pyrazol
  参考文献：
  名称：

  Grandberg,I.I. et al., Journal of general chemistry of the USSR, 1960, vol. 30, p. 2896 - 2900

  摘要：

  DOI：

文献信息

• Novel high affinity thiophene-based and furan-based kinase ligands
  申请人：Deng Yongqi

  公开号：US20070043045A1

  公开（公告）日：2007-02-22

  Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

  描述了抑制细胞周期依赖性激酶2（CDK-2）的抑制剂、包括这些抑制剂的组合物，以及使用这些抑制剂和抑制剂组合物的方法。这些抑制剂和包括它们的组合物对于治疗疾病或疾病症状是有用的。该发明还提供了制备CDK-2抑制剂化合物的方法、抑制CDK-2的方法，以及治疗疾病或疾病症状的方法。
• Pyrimidine derivatives as kinase inhibitors and their therapeutical applications
  申请人：NantBioScience, Inc.

  公开号：US10766879B2

  公开（公告）日：2020-09-08

  The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.

  本发明提供了由取代的嘧啶衍生物组成的抗肿瘤剂及其药学上可接受的制剂、新型化合物的制造方法和化合物的使用方法。根据本发明的化合物和组合物可用于治疗多种疾病，并具有激酶抑制活性。
• Trk inhibition
  申请人：NantBio, Inc.

  公开号：US10800760B2

  公开（公告）日：2020-10-13

  The present invention relates to the use of substituted pyrazole derivatives to modulate tropomyosin-related kinase (Trk) family protein kinase, and the use of the substituted pyrazole derivatives for the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

  本发明涉及使用取代的吡唑衍生物来调节肌球蛋白相关激酶（Trk）家族蛋白激酶，以及使用取代的吡唑衍生物来治疗疼痛、炎症、癌症、血管再狭窄、动脉粥样硬化、牛皮癣、血栓形成、与髓鞘脱落或脱髓鞘有关的疾病、紊乱、损伤或功能障碍，或与神经生长因子（NGF）受体TrkA的异常活动有关的疾病或紊乱。
• PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS
  申请人：NantBioScience, Inc.

  公开号：US20180155327A1

  公开（公告）日：2018-06-07

  The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
• US7446195B2
  申请人：——

  公开号：US7446195B2

  公开（公告）日：2008-11-04