2-(4-bromo-phenylamino)-4-methyl-thiazole-5-carboxylic acid | 890082-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-bromo-phenylamino)-4-methyl-thiazole-5-carboxylic acid
• 英文别名: 2-(4-Bromoanilino)-4-methyl-1,3-thiazole-5-carboxylic acid
• CAS: 890082-07-2
• 化学式: C₁₁H₉BrN₂O₂S
• mdl: MFCD08165209
• 分子量: 313.175
• InChiKey: BHUGJXNXMIEUPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(4-bromo-phenylamino)-4-methyl-thiazole-5-carboxylic acid 、 (S)-(-)-1-(2-萘基)乙胺 在 1-羟基苯并三唑 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.5h， 生成 2-(4-fluoro-phenylamino)-4-methyl-thiazole-5-carboxylic acid (S)-1-(naphthalen-2-yl)ethylamide
  参考文献：
  名称：

  WO2006/58905

  摘要：

  公开号：

文献信息

• 5-CARBOXAMIDO SUBSTITUED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE KV FAMILY
  申请人：Devgen N.V.

  公开号：EP1819330A1

  公开（公告）日：2007-08-22
• 5-Carboxamido Substituted Thiazole Derivatives that Interact With Ion Channels, In Particular With Ion Channels From the Kv Family
  申请人：Blom Petra

  公开号：US20080125432A1

  公开（公告）日：2008-05-29

  The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula having the structural Formula I, II, III or IV, stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, Y 1 , Y 2 , R 1 , n, R 3 , R 8 , R 9 , R 10 , L 1 , L 2 , Ar 1 and Ar 2 are defined in claim 1 . The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
• [EN] 5-CARBOXAMIDO SUBSTITUTED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE Kv FAMILY<br/>[FR] DÉRIVÉS DE THIAZOLE SUBSTITUÉ PAR DU 5-CARBOXAMIDO QUI INTERAGISSENT AVEC DES CANAUX IONIQUES, EN PARTICULIER AVEC DES CANAUX IONIQUES DE LA FAMILLE DE Kv
  申请人：DEVGEN NV

  公开号：WO2006058905A1

  公开（公告）日：2006-06-08

  [EN] The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, Y¹, Y², R¹, n, R³, R⁸, R⁹, R¹⁰, L¹, L², Ar¹ and Ar² are defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
  [FR] La présente invention concerne des composés qui interagissent avec des canaux ioniques. En particulier, l'invention concerne des composés ayant la formule structurelle (I), (II), (III) ou (IV), des stéréo-isomères, des tautomères, des racémiques, des promédicaments, des métabolites de ceux-ci, ou un sel pharmaceutiquement acceptable et/ou un solvate de ceux-ci, où X, Y¹, Y², R¹, n, R³, R⁸, R⁹, R¹⁰, L¹, L², Ar¹ et Ar² sont définis dans la revendication 1. La présente invention concerne également des procédés de préparation desdits composés, des compositions pharmaceutiques comprenant lesdits composés et l'utilisation desdits composés dans des procédés de traitement des corps humain et animal.
• WO2006/58905
  申请人：——

  公开号：——

  公开（公告）日：——