(2R,3aS,3'aS,4S,5S,6'R,6'aR)-6'-methoxy-4,5-bis(methoxymethoxy)-2',2'-dimethylspiro[3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b][1,2]oxazole-2,4'-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole] | 390414-90-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3aS,3'aS,4S,5S,6'R,6'aR)-6'-methoxy-4,5-bis(methoxymethoxy)-2',2'-dimethylspiro[3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b][1,2]oxazole-2,4'-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole]
• CAS: 390414-90-1
• 化学式: C₁₇H₂₉NO₉
• 分子量: 391.419
• InChiKey: OAZAOPPHOJEZBE-HDGVANAFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  86.3
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (2R,3aS,3'aS,4S,5S,6'R,6'aR)-6'-methoxy-4,5-bis(methoxymethoxy)-2',2'-dimethylspiro[3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b][1,2]oxazole-2,4'-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole] 在 镍 sodium tetrahydroborate 、 氢气 、 硼酸 、 magnesium sulfate 作用下， 以 甲醇 为溶剂， 反应 28.0h， 生成 (3aS,6S,7S,7aS,9aR)-6,7-Bis-methoxymethoxy-2,2-dimethyl-octahydro-1,3-dioxa-4a-aza-cyclopenta[f]azulen-9-ol
  参考文献：
  名称：

  Expeditious synthesis of seven-membered iminocyclitols

  摘要：

  A concise synthesis of an azepanetriol and an octahydropyrrolo[1,2-a]azepinepentol. by nitrone addition to a pent-4-enofuranoside derived from D-ribose, Followed by reductive opening of the isoxazolidine ring formed. is reported. (C). 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01587-8
• 作为产物：
  描述：

  methyl 5-deoxy-2,3-O-isopropylidene-β-D-erythro-pent-4-enofuranoside 、 (3S,4S)-3,4-Bis(methoxymethoxy)-1-pyrroline N-Oxide 以 甲苯 为溶剂， 反应 48.0h， 生成 、 (2R,3aS,3'aS,4S,5S,6'R,6'aR)-6'-methoxy-4,5-bis(methoxymethoxy)-2',2'-dimethylspiro[3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b][1,2]oxazole-2,4'-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole]
  参考文献：
  名称：

  Expeditious synthesis of seven-membered iminocyclitols

  摘要：

  A concise synthesis of an azepanetriol and an octahydropyrrolo[1,2-a]azepinepentol. by nitrone addition to a pent-4-enofuranoside derived from D-ribose, Followed by reductive opening of the isoxazolidine ring formed. is reported. (C). 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01587-8

文献信息

• Expeditious synthesis of seven-membered iminocyclitols
  作者：John K Gallos、Soultana C Demeroudi、Constantina C Stathopoulou、Constantinos C Dellios

  DOI：10.1016/s0040-4039(01)01587-8

  日期：2001.10

  A concise synthesis of an azepanetriol and an octahydropyrrolo[1,2-a]azepinepentol. by nitrone addition to a pent-4-enofuranoside derived from D-ribose, Followed by reductive opening of the isoxazolidine ring formed. is reported. (C). 2001 Elsevier Science Ltd. All rights reserved.