1-(3-{[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)ethanone | 315706-16-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-{[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)ethanone
• 英文别名: 1-[3-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenyl]ethanone
• CAS: 315706-16-2
• 化学式: C₁₇H₁₃ClN₂OS
• 分子量: 328.822
• InChiKey: IUKRMLCSMHLRGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间氨基苯乙酮 在 盐酸 、 三乙胺 作用下， 以 乙醇 、 水 为溶剂， 反应 16.0h， 生成 1-(3-{[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)ethanone
  参考文献：
  名称：

  Synthesis and antibacterial activity of 2-(3-acylphenyl)amino-4-phenylthiazole

  摘要：

  2-(3-acylphenyl)amino-4-phenylthiazoles were synthesized from 1-(3-acetylphenyl)thiourea and 2-bromo-1-substituted phenylethanones in presence of triethylamine upon heating. The newly synthesized compounds were characterized by IR, H-1 NMR, MS spectrometry. All products were evaluated for their antibacterial activity against Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative (Escherichia coli, Klebsiella pnemoniae) strains.

  DOI：

  10.1134/s1070363215030275

文献信息

• Synthesis and antibacterial activity of 2-(3-acylphenyl)amino-4-phenylthiazole
  作者：N. J. P. Subhashini、Jampaiah Amanaganti、Shivaraj

  DOI：10.1134/s1070363215030275

  日期：2015.3

  2-(3-acylphenyl)amino-4-phenylthiazoles were synthesized from 1-(3-acetylphenyl)thiourea and 2-bromo-1-substituted phenylethanones in presence of triethylamine upon heating. The newly synthesized compounds were characterized by IR, H-1 NMR, MS spectrometry. All products were evaluated for their antibacterial activity against Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative (Escherichia coli, Klebsiella pnemoniae) strains.