9-phenyl-6,6-dimethyl-1,8-dioxo-1,3,4,5,7,8-dodecahydrofuro<3,4-b>quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-phenyl-6,6-dimethyl-1,8-dioxo-1,3,4,5,7,8-dodecahydrofuro<3,4-b>quinoline
• 英文别名: 6,6-dimethyl-9-phenyl-4,5,7,9-tetrahydro-3H-furo[3,4-b]quinoline-1,8-dione
• 化学式: C₁₉H₁₉NO₃
• 分子量: 309.365
• InChiKey: BWZMWJYWPHMNCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 1,4,7,8-tetrahydro-2,7,7-trimethyl-4-phenyl-5(6H)-oxoquinoline-3-carboxylate 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 氯仿 为溶剂， 反应 4.0h， 以65%的产率得到9-phenyl-6,6-dimethyl-1,8-dioxo-1,3,4,5,7,8-dodecahydrofuro<3,4-b>quinoline
  参考文献：
  名称：

  Bosque, Jose R. Del; Martin, Nazario; Mora, Arturo, Anales de Quimica, 1994, vol. 90, # 7-8, p. 511 - 512

  摘要：

  DOI：

文献信息

• Del Bosque Jose R., Martin Nazario, Mora Arturo, Morales Alhmed, Quinteir+, An quim, 90 (1994) N 7-8, S 511-512
  作者：Del Bosque Jose R., Martin Nazario, Mora Arturo, Morales Alhmed, Quinteir+

  DOI：——

  日期：——
• DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE
  申请人：ABBOTT LABORATORIES

  公开号：EP1131322A2

  公开（公告）日：2001-09-12
• [EN] DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSES DE DIHYDROPYRIDINE ET LEUR MODE D'UTILISATION
  申请人：ABBOTT LAB

  公开号：WO2000024741A2

  公开（公告）日：2000-05-04

  Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
• [EN] DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSES DE DIHYDROPYRIDINE ET PROCEDES D'UTILISATION
  申请人：ABBOTT LAB

  公开号：WO2001083480A2

  公开（公告）日：2001-11-08

  Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.