2,5-Dimethoxy-tetrahydro-furan-2-carboxylic acid | 60512-79-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-Dimethoxy-tetrahydro-furan-2-carboxylic acid
• 英文别名: 2,5-Dimethoxyoxolane-2-carboxylic acid
• CAS: 60512-79-0
• 化学式: C₇H₁₂O₅
• 分子量: 176.169
• InChiKey: MRNYLDFLQAVJTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,5-Dimethoxy-tetrahydro-furan-2-carboxylic acid 、 6-amino-7-trifluoromethyl-2,3(1H,4H)-quinoxalinedione 在 溶剂黄146 作用下， 反应 0.5h， 生成 1-(2,3-Dioxo-7-trifluoromethyl-1,2,3,4-tetrahydro-quinoxalin-6-yl)-1H-pyrrole-2-carboxylic acid
  参考文献：
  名称：

  Pyrrolylquinoxalinediones: The importance of pyrrolic substitution on AMPA receptor binding

  摘要：

  Pyrrolylquinoxalinediones were synthesized to elucidate the value of pyrrolic substitution pattern on AMPA receptor binding. We discovered that amide and urea residues at the 3'-position at pyrrol ring favor affinity to AMPA receptor. Particularly, the phenylurea 13n exhibited a K-i value of 4 nM in AMPA receptor binding and represents the most potent competitive AMPA antagonist reported to dare. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00170-4

文献信息

• Pyrrolylquinoxalinediones: The importance of pyrrolic substitution on AMPA receptor binding
  作者：W. Lubisch、B. Benl、H.P. Hofmann

  DOI：10.1016/s0960-894x(97)00170-4

  日期：1997.5

  Pyrrolylquinoxalinediones were synthesized to elucidate the value of pyrrolic substitution pattern on AMPA receptor binding. We discovered that amide and urea residues at the 3'-position at pyrrol ring favor affinity to AMPA receptor. Particularly, the phenylurea 13n exhibited a K-i value of 4 nM in AMPA receptor binding and represents the most potent competitive AMPA antagonist reported to dare. (C) 1997 Elsevier Science Ltd.