N-(苯基氨基甲酰基)氨基甲酸乙酯 | 24774-92-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(苯基氨基甲酰基)氨基甲酸乙酯
• 英文名称: N¹-Aethoxycarbonyl-N²-phenylthioharnstoff
• 英文别名: ethyl N-(phenylcarbamothioyl)carbamate；N-phenyl-N'-ethoxycarbonylthiourea；4-phenyl-3-thio-allophanic acid ethyl ester；4-Phenyl-3-thio-allophansaeure-aethylester；ω-Phenyl-thioallphansaeure-aethylester；N-Phenyl-thioharnstoff-N'-carbonsaeureaethylester；Carbamic acid, [(phenylamino)thioxomethyl]-, ethyl ester
• CAS: 24774-92-3
• 化学式: C₁₀H₁₂N₂O₂S
• 分子量: 224.283
• InChiKey: LABDDSVDEIPQAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  82.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(苯基氨基甲酰基)氨基甲酸乙酯 在 氯化亚砜 、 caesium carbonate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 6.0h， 生成 (Z)-ethyl (4-methyl-3-phenylthiazol-2(3H)-ylidene)carbamate
  参考文献：
  名称：

  [EN] PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS
  [FR] COMPOSITIONS DE PYRROLO [2,3-B] PYRIDINE-3-CARBOXAMIDE ET PROCÉDÉS POUR AMÉLIORER LA PERTE AUDITIVE

  摘要：

  N-(3-取代噻唑-2(3H)-基)-1H-吡咯并[2,3-b]吡啶-3-羧酰胺和N-(3-取代噁唑-2(3H)-基)-1H-吡咯并[2,3-b]吡啶-3-羧酰胺（I）和（II）已被披露。这些化合物激活Yap并抑制Lats激酶。因此，它们对治疗听力损失是有用的。

  公开号：

  WO2021158936A1
• 作为产物：
  描述：

  1-乙酰基-3-苯基硫脲 、 氯甲酸乙酯 生成 N-(苯基氨基甲酰基)氨基甲酸乙酯
  参考文献：
  名称：

  Seidel, Journal fur praktische Chemie (Leipzig 1954), 1885, vol. <2>32, p. 273

  摘要：

  DOI：

文献信息

• QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS
  申请人：Bembenek Scott D.

  公开号：US20100204226A1

  公开（公告）日：2010-08-12

  Quinazolinone compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  公式（I）的喹唑啉酮化合物被描述为脯氨酸羟化酶抑制剂，这些化合物可用于制药组合物和治疗由脯氨酸羟化酶活性介导的疾病状态、紊乱和情况的方法。因此，这些化合物可用于治疗贫血、血管紊乱、代谢紊乱和伤口愈合等疾病。
• Studies on Organic Sulfur Compounds. XIII. The Oxidation Reaction of Alkoxycarbonylthioureas with Bromine
  作者：MITSUO NAGANO、MICHIKO OSHIGE、TAKASHI MATSUI、JUNZO TOBITSUKA、KOZO OYAMADA

  DOI：10.1248/cpb.21.2396

  日期：——

  N-Alkoxycarbonylthioureas (A) were reacted with bromine in CHCl3 to afford sulfur, alkoxycarbonylureas (B), 3, 5-bis (alkoxycarbonylimino)-1, 2, 4-dithiazolidines (C), 3, 5-bis-(alkoxycarbonylamino)-1, 2, 4-thiadiazoles (D), 2-alkoxycarbonyl-5-alkoxycarbonylamino-3-imino-1, 2, 4-thiadiazolines (E) and 3-amino-5-alkoxycarbonylamino-1, 2, 4-thiadiazoles (F). This paper describes in detail on the confirmation of the structures of these reaction products.

  N-烷氧基羰基硫脲（A）与溴在氯仿中反应，生成硫、烷氧基羰基脲（B）、3, 5-双（烷氧基羰基亚氨基）-1, 2, 4-二硫杂戊烷（C）、3, 5-双（烷氧基羰基氨基）-1, 2, 4-噻二唑（D）、2-烷氧基羰基-5-烷氧基羰基氨基-3-亚氨基-1, 2, 4-噻二唑啉（E）和3-氨基-5-烷氧基羰基氨基-1, 2, 4-噻二唑（F）。本文详细描述了这些反应产物结构的确认。
• TMEDA-CATALYZED SYNTHESIS OF <i>N</i>-ARYL-<i>N</i>′-ETHOXYCARBONYL THIOUREA AND ARENE (OR POLYMETHYLENE)-BIS-ETHOXYCARBONYLTHIOUREA DERIVATIVES
  作者：Qi Lin、You-Ming Zhang、Li-Ming Gao、Tai-Bao Wei、Hai Wang

  DOI：10.1080/10426500490474905

  日期：2004.10.1

  A novel and efficient method for synthesis ethoxycarbonyl isothiocyanate and ethoxycarbonyl thioureas catalyzed by TMEDA is reported. A series of N-aryl-N′-ethoxycarbonyl thioureas and arene (or polymethylene)-bis-ethoxycarbonyl thiourea derivatives have been synthesized in good-to-excellent yields via this method at room temperature.

  报道了一种由 TMEDA 催化合成乙氧羰基异硫氰酸酯和乙氧羰基硫脲的新方法。通过该方法在室温下合成了一系列N-芳基-N'-乙氧基羰基硫脲和芳烃（或聚亚甲基）-双-乙氧基羰基硫脲衍生物，产率从良好到优异。
• 4-AMINOQUINAZOLIN-2-YL-1-PYRRAZOLE-4-CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS
  申请人：Rabinowitz Michael H.

  公开号：US20130143871A1

  公开（公告）日：2013-06-06

  Aminoquinazolinyl compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  描述了化学式（I）的氨基喹唑啉化合物，可用作脯氨酸羟化酶抑制剂。这种化合物可用于制备药物组合物和治疗由脯氨酸羟化酶活性介导的疾病状态、紊乱和病情的方法。因此，这些化合物可用于治疗贫血、血管疾病、代谢性疾病和伤口愈合等疾病。
• 4-Aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20150197507A1

  公开（公告）日：2015-07-16

  Aminoquinazolinyl compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

  描述了式(I)的氨基喹唑啉化合物，其作为丙氨酸羟化酶抑制剂是有用的。这样的化合物可以用于药物组合物和治疗由丙氨酸羟化酶活性介导的疾病状态、紊乱和病况的方法。因此，这些化合物可以被用于治疗贫血、血管紊乱、代谢紊乱和创伤愈合等疾病。

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