(E)-3-(3-Bromo-4-fluorophenyl)acryloyl chloride | 676348-50-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(3-Bromo-4-fluorophenyl)acryloyl chloride
• 英文别名: (E)-3-(3-bromo-4-fluorophenyl)prop-2-enoyl chloride
• CAS: 676348-50-8
• 化学式: C₉H₅BrClFO
• 分子量: 263.494
• InChiKey: HFINYPSPUVAVCC-DUXPYHPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2916399090

反应信息

• 作为反应物：
  描述：

  4-{2-hydroxy-1-[4-(1H-indol-3-yl)-hexahydropyridin-1-yl]-ethyl}-hexahydropyridine 、 (E)-3-(3-Bromo-4-fluorophenyl)acryloyl chloride 生成 (E)-3-(3-bromo-4-fluorophenyl)-1-[4-[2-hydroxy-1-[4-(1H-indol-3-yl)piperidin-1-yl]ethyl]piperidin-1-yl]prop-2-en-1-one
  参考文献：
  名称：

  Substituted dipiperidine alcohols as potent CCR2 antagonists

  摘要：

  The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure-activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC(50) values in the nanomolar or subnanomolar range. The cinnamoyl compounds had higher binding affinities than the corresponding urea analogs. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.010

文献信息

• 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVE OR SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：YUHAN CORPORATION

  公开号：US20150291563A1

  公开（公告）日：2015-10-15

  The present invention provides a 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt effectively increases the LXR transcriptional activity, and therefore can be usefully applied for preventing or treating a dysfunction in cholesterol metabolism, such as cholesterol gallstone, hyperlipidemia, or coronary atherosclerosis.

  本发明提供了一种4,5-二氢-1H-吡唑烷衍生物或其药用可接受盐，以及其制备方法和包含该衍生物的药物组合物。4,5-二氢-1H-吡唑烷衍生物或其药用可接受盐有效增加LXR转录活性，因此可以有效地用于预防或治疗胆固醇代谢功能障碍，如胆固醇结石、高脂血症或冠状动脉粥样硬化。
• US9376420B2
  申请人：——

  公开号：US9376420B2

  公开（公告）日：2016-06-28
• Substituted dipiperidine alcohols as potent CCR2 antagonists
  作者：Mingde Xia、Cuifen Hou、Duane DeMong、Scott Pollack、Meng Pan、James Brackley、Monica Singer、Michele Matheis、Druie Cavender、Michael Wachter

  DOI：10.1016/j.bmcl.2008.05.010

  日期：2008.6

  The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure-activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC(50) values in the nanomolar or subnanomolar range. The cinnamoyl compounds had higher binding affinities than the corresponding urea analogs. (C) 2008 Elsevier Ltd. All rights reserved.