bromoisobutyrate | 18526-77-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bromoisobutyrate
• 英文别名: α-Brom-isobutyratanion；2-Bromo-2-methylpropanoate
• CAS: 18526-77-7
• 化学式: C₄H₆BrO₂
• 分子量: 165.994
• InChiKey: XXSPGBOGLXKMDU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,4'-二氨基二苯二硫醚 、 bromoisobutyrate 在 bipyridine 作用下， 以 氯仿 为溶剂， 反应 10.0h， 以95%的产率得到2-bromo-N-[4-[[4-[(2-bromo-2-methylpropanoyl)amino]phenyl]disulfanyl]phenyl]-2-methylpropanamide
  参考文献：
  名称：

  Chemical Functionalization of Carbon Supported Metal Nanoparticles by Ionic Conductive Polymer via the “Grafting From” Method

  摘要：

  favor Platinum nanoparticles (Pt-NPs) supported on carbon powder are prepared via a water-in-oil microemulsion method and modified by a disulfide aryl initiator either by a postgrafting method or by a one pot in situ "grafting from" method. It is shown that the grafting of the disulfide derivation initiator is quantitative from 2 to 10 wt %, independently on the method. ATRP of sodium styrene sulfonate (SSNa) has then been performed from the initiator molecules grafted on the surface of the Pt-NPs supported on an electron conductive porous substrate and electrochemical measurements are performed. Although the polymerization reaction was not total (60%), derivatization of the Pt-NPs-initiator/C with different polymerization densities and polymer molecular weights are obtained. Electrodes fabricated from such nanocomposites shows enhanced performances toward the oxygen reduction reaction. Higher activity is obtained with lower polymerization density and higher polymer molecular weight. The enhancement of activity is attributed to the difference in hydrophilic character between the polymer skeleton (which could favor oxygen transport toward active sites) and the pendant sulfonic acid groups (which favor the proton transport toward the active sites).

  DOI：

  10.1021/cm401264f
• 作为产物：
  描述：

  Azide propanol 、 2-溴-2-甲基丙酰溴 、 、 、 五甲基二乙烯三胺 、 N,N-二甲基甲酰胺 在 alkyne 、 二氯甲烷 、 铜 、 正己烷 作用下， 以 四氢呋喃 为溶剂， 反应 40.0h， 生成 叠氮阴离子 、 bromoisobutyrate
  参考文献：
  名称：

  Process for the preparation of a cross-linked multilayer film

  摘要：

  本发明提供了一种多层膜的制备方法，特别是交联多层大分子膜的制备方法。

  公开号：

  US20110250353A1

文献信息

• Biphenyloxy derivatives and antihyperlipidemic use
  申请人：Boehringer Ingelheim GmbH

  公开号：US04010279A1

  公开（公告）日：1977-03-01

  Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms, R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms, R.sub.3 is hydroxymethyl, carboxyl, alkoxycarbonyl of 2 to 7 carbon atoms or cycloalkoxycarbonyl or 4 to 8 carbon atoms, A is --CO--NH-- or --NH--CO--, and n is 1, 2 or 3, And, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antihyperlipidemics.

  该化合物的公式为##STR1##其中R.sub.1是1至6个碳原子的直链或支链烷基，3至6个碳原子的环烷基，苯基烷基，苯基烯基，吡啶基或##STR2##其中X、Y和Z分别为氢，卤素，1至3个碳原子的烷基或1至3个碳原子的烷氧基，R.sub.2为氢或1至4个碳原子的烷基，R.sub.3为羟甲基，羧基，2至7个碳原子的烷氧羰基或4至8个碳原子的环烷氧羰基，A为--CO--NH--或--NH--CO--，n为1、2或3。当R.sub.3为羧基时，与无机或有机碱形成的非毒性盐；这些化合物以及盐在抗高脂血症方面有用。
• Polymerization process with living characteristics and polymers made therefrom
  申请人：——

  公开号：US20040024132A1

  公开（公告）日：2004-02-05

  A free radical polymerization process suitable for synthesizingpolymers is disclosed. The process utilizes novel sulfur based chain transfer agents and is widely compatible over a range of monomers and reaction conditions. Novel polymers having low polydispersity and predictable specific polymer architecture amd molecular weight are produced by the process. The polymers produced by the process are suitable for use as binders in automotive OEM and refinish coatings.

  本文披露了适用于合成聚合物的自由基聚合过程。该过程利用新型基于硫的链转移剂，并且在各种单体和反应条件下广泛兼容。该过程生产具有低聚分散度和可预测的特定聚合物结构和分子量的新型聚合物。该过程生产的聚合物适用于作为汽车OEM和修补涂料中的粘合剂。
• Compounds And Compositions As Ppar Modulators
  申请人：Epple Robert

  公开号：US20070203155A1

  公开（公告）日：2007-08-30

  The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.

  本发明提供了化合物、包含这些化合物的药物组合物以及使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体（PPAR）家族的活性相关的疾病或障碍的方法，特别是与PPAR的活性相关的疾病或障碍的方法。
• Propionic acid derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US06548538B2

  公开（公告）日：2003-04-15

  The present application relates to novel potent PPAR-alpha-activating compounds for treating, for example, coronary heart disease, and to their preparation.

  本申请涉及一种用于治疗冠心病等疾病的新型有效PPAR-alpha激活化合物及其制备。
• 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS
  申请人：Bombrun Agnes

  公开号：US20130116289A1

  公开（公告）日：2013-05-09

  The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.

  本发明提供了式（I）的化合物，作为选择性S1P1抑制剂，以及它们用于治疗多发性硬化症和其他疾病的用途。