1-[3,5-Bis(trifluoromethyl)phenyl]pyrazole | 1326271-88-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[3,5-Bis(trifluoromethyl)phenyl]pyrazole
• CAS: 1326271-88-8
• 化学式: C₁₁H₆F₆N₂
• 分子量: 280.172
• InChiKey: RXAQWLKWFWHBEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  吡唑 、 3,5-双三氟甲基溴苯 在 caesium carbonate 作用下， 以 二甲基亚砜 为溶剂， 以61%的产率得到1-[3,5-Bis(trifluoromethyl)phenyl]pyrazole
  参考文献：
  名称：

  Nitrogen-rich copolymeric microsheets supporting copper nanoparticles for catalyzing arylation of N-heterocycles

  摘要：

  Nitrogen-rich copolymeric microsheets were synthesized through incomplete condensation of melamine and cyanuric chloride. The materials can be well-dispersed in polar solvent and perform excellently as supports or stabilizing agents for metal nanoparticles. The presence of nitrogen in the lattice improves their interaction with the copper nanoparticle precursor (Cu(II) ions). Monodispersed copper nanoparticles over these supports were obtained after reducing the absorbed precursors. The materials were characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The catalytic C-N coupling reaction was selected as the model reaction to evaluate the catalytic performance of the supported nanoparticles. The catalysts show above 90% yield of coupling products and retain activity after a five-run recycling test. Surface chemistry and morphology transforming during the catalytic process was further investigated. Nitrogen-rich copolymeric microsheets were proven to be excellent supports and stabilizing agents for metal nanoparticles. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2011.06.019

文献信息

• Nitrogen-rich copolymeric microsheets supporting copper nanoparticles for catalyzing arylation of N-heterocycles
  作者：Zhijun Huang、Fengbo Li、Bingfeng Chen、Fei Xue、Guochang Chen、Guoqing Yuan

  DOI：10.1016/j.apcata.2011.06.019

  日期：2011.8

  Nitrogen-rich copolymeric microsheets were synthesized through incomplete condensation of melamine and cyanuric chloride. The materials can be well-dispersed in polar solvent and perform excellently as supports or stabilizing agents for metal nanoparticles. The presence of nitrogen in the lattice improves their interaction with the copper nanoparticle precursor (Cu(II) ions). Monodispersed copper nanoparticles over these supports were obtained after reducing the absorbed precursors. The materials were characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The catalytic C-N coupling reaction was selected as the model reaction to evaluate the catalytic performance of the supported nanoparticles. The catalysts show above 90% yield of coupling products and retain activity after a five-run recycling test. Surface chemistry and morphology transforming during the catalytic process was further investigated. Nitrogen-rich copolymeric microsheets were proven to be excellent supports and stabilizing agents for metal nanoparticles. (C) 2011 Elsevier B.V. All rights reserved.