5-acetyl-4-amino-2-(3-bromopropyl)-6-methylpyridazin-3(2H)-one | 1192490-68-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-acetyl-4-amino-2-(3-bromopropyl)-6-methylpyridazin-3(2H)-one
• 英文别名: 5-Acetyl-4-amino-2-(3-bromopropyl)-6-methylpyridazin-3-one
• CAS: 1192490-68-8
• 化学式: C₁₀H₁₄BrN₃O₂
• 分子量: 288.144
• InChiKey: VCKKGWGHJWROEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-甲基哌啶 、 5-acetyl-4-amino-2-(3-bromopropyl)-6-methylpyridazin-3(2H)-one 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以38%的产率得到5-acetyl-4-amino-6-methyl-2-[3-(4-methylpiperidin-1-yl)propyl]pyridazin-3(2H)-one
  参考文献：
  名称：

  Further Studies on Arylpiperazinyl Alkyl Pyridazinones: Discovery of an Exceptionally Potent, Orally Active, Antinociceptive Agent in Thermally Induced Pain

  摘要：

  A number of pyridazinone derivatives bearing all arylpiperazinylalkyl chain were synthesized and tested icv in it model of acute nociception induced by thermal stimuli in mice (tail flick). The most interesting and potent compound in this series was 6a, which showed an ED50 = 3.5 mu g, a value about 3-fold higher with respect to morphine by the same route of administration. When administered per os, 6a was 4-fold more potent than morphine in the same test, suggesting it significant bioavailability. The same compound also showed high potency in the hot plate test. The antinociceptive effect of 6a was completely reversed by pretreatment with yohimbine both in the hot plate test and in the tail flick test. This demonstrated the involvement of the adrenergic system, which was confirmed by in vitro radioligand binding studies.

  DOI：

  10.1021/jm900458r
• 作为产物：
  描述：

  1,3-二溴丙烷 、 5-乙酰基-4-氨基-6-甲基-2H-吡嗪-3-酮 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以20%的产率得到5-acetyl-4-amino-2-(3-bromopropyl)-6-methylpyridazin-3(2H)-one
  参考文献：
  名称：

  Further Studies on Arylpiperazinyl Alkyl Pyridazinones: Discovery of an Exceptionally Potent, Orally Active, Antinociceptive Agent in Thermally Induced Pain

  摘要：

  A number of pyridazinone derivatives bearing all arylpiperazinylalkyl chain were synthesized and tested icv in it model of acute nociception induced by thermal stimuli in mice (tail flick). The most interesting and potent compound in this series was 6a, which showed an ED50 = 3.5 mu g, a value about 3-fold higher with respect to morphine by the same route of administration. When administered per os, 6a was 4-fold more potent than morphine in the same test, suggesting it significant bioavailability. The same compound also showed high potency in the hot plate test. The antinociceptive effect of 6a was completely reversed by pretreatment with yohimbine both in the hot plate test and in the tail flick test. This demonstrated the involvement of the adrenergic system, which was confirmed by in vitro radioligand binding studies.

  DOI：

  10.1021/jm900458r