N-methyl-2-methoxypyrrole | 89464-27-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-methyl-2-methoxypyrrole
• 英文别名: 1-Methyl-2-methoxy-pyrrol；2-methoxy-1-methyl-pyrrole；2-Methoxy-1-methylpyrrole
• CAS: 89464-27-7
• 化学式: C₆H₉NO
• 分子量: 111.144
• InChiKey: AKBDNEFWDAEIJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  14.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基吡咯 生成 N-methyl-2-methoxypyrrole
  参考文献：
  名称：

  CERICHELLI, GIORGIO;CRESTONI, MARIA ELISA;FORNARINI, SIMONETTA, GAZZ. CHIM. ITAL., 120,(1990) N2, C. 749-755

  摘要：

  DOI：

文献信息

• Copper(I) halide catalysed synthesis of alkyl aryl and alkyl heteroaryl ethers
  作者：Menno A. Keegstra、Theo H.A. Peters、Lambert Brandsma

  DOI：10.1016/s0040-4020(01)88501-x

  日期：1992.1

  A number of alkyl aryl and alkyl heteroaryl ethers have been prepared from (hetero) aryl halides (mainly bromides) and sodium alkoxides, using copper(I)bromide as a catalyst. The influence of the main solvent, the halogen atom, reaction temperature and the presence of oxygen upon the rate and selectivity has been studied. Furthermore the decomposition of the catalyst and the reduction of the aryl halide

  使用溴化铜（I），由（杂）芳基卤化物（主要是溴化物）和醇钠制备了许多烷基芳基和烷基杂芳基醚。研究了主要溶剂，卤素原子，反应温度和氧的存在对反应速率和选择性的影响。此外，还研究了催化剂的分解和芳基卤化物的还原。
• Broad Spectrum Antiviral and Antiparasitic Agents
  申请人：Lee Benhur

  公开号：US20130028966A1

  公开（公告）日：2013-01-31

  The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic infections. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds.

  本发明提供了公式（I）和（II）所代表的化合物，这些化合物可用于治疗病毒和/或寄生虫感染等疾病。本发明还提供了包含这些化合物的制药组合物以及使用这些化合物进行治疗的方法。
• HETEROCYCLIC COMPOUND
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20150141406A1

  公开（公告）日：2015-05-21

  The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种具有优异的JAK抑制作用的化合物，可用作自身免疫性疾病（类风湿性关节炎、银屑病、炎症性肠病、干燥综合征、Behcet病、多发性硬化症、系统性红斑狼疮等）、癌症（白血病、子宫平滑肌肉肉瘤、前列腺癌、多发性骨髓瘤、消瘦、骨髓纤维化等）等的预防或治疗剂，或其盐。本发明涉及一个由公式表示的化合物，其中每个符号如规范中所定义，或其盐。
• BROAD SPECTRUM ANTIVIRAL AND ANTIPARASITIC AGENTS
  申请人：The Regents of the University of California

  公开号：US20160207908A1

  公开（公告）日：2016-07-21

  The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic infections. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds.

  该发明提供了由公式（I）和（II）表示的化合物，这些化合物在治疗例如病毒性和/或寄生虫感染方面非常有用。还提供了包含这些化合物的药物组合物以及使用这些化合物的治疗方法。
• Organic semiconductor formulations
  申请人：Flexterra, Inc.

  公开号：US10043978B2

  公开（公告）日：2018-08-07

  The present teachings relate to organic semiconductor formulations including an organic semiconducting compound in a liquid medium, where the liquid medium includes (1) a compound in liquid state that has electronic properties complementary to the electronic structure of the organic semiconducting compound and optionally (2) a solvent or solvent mixture for solubilizing the organic semiconducting compound. The present formulations can be used as inks in the fabrication of organic semiconductor devices.

  本发明涉及有机半导体制剂，包括液体介质中的有机半导体化合物，其中液体介质包括（1）液态化合物，该化合物具有与有机半导体化合物电子结构互补的电子特性，以及（2）用于溶解有机半导体化合物的溶剂或溶剂混合物。本制剂可用作制造有机半导体器件的油墨。