(2S)-2-fluoropropan-1-ol | 877822-87-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: (2S)-2-fluoropropan-1-ol
• CAS: 877822-87-2
• 化学式: C₃H₇FO
• 分子量: 78.0864
• InChiKey: WKXZJCKWUCBECD-VKHMYHEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2S)-2-fluoropropan-1-ol 、 N-[6-(methoxymethoxy)-2,3-dihydro-1H-inden-5-yl]-4-methyl-1,3-thiazole-2-sulfonamide 在 三丁基膦 、 偶氮二甲酰二哌啶 作用下， 以 四氢呋喃 为溶剂， 生成 N-[(2S)-2-fluoropropyl]-N-[6-(methoxymethoxy)-2,3-dihydro-1H-inden-5-yl]-4-methyl-1,3-thiazole-2-sulfonamide
  参考文献：
  名称：

  EP2305641

  摘要：

  公开号：

文献信息

• SULFONAMIDE COMPOUNDS OR SALTS THEREOF
  申请人：Kubota Hideki

  公开号：US20110201616A1

  公开（公告）日：2011-08-18

  [Object] A compound which is useful as an EP1 receptor antagonist is provided. [Means for Solution] The present inventors investigated EP1 receptor antagonists, and confirmed that a compound having a sulfonamide structure, in which the nitrogen atom of the sulfonamide structure is substituted with 2-fluoropropyl group, 3-fluoro-2-methylpropyl group or the like, has a potent EP1 receptor antagonistic action, thereby completing the present invention. The sulfonamide compound of the present invention has a potent EP1 receptor antagonistic action and can be used as an agent for preventing and/or treating a lower urinary tract symptom or the like.

  [物件] 提供了一种作为EP1受体拮抗剂有用的化合物。 [解决方案手段] 现有发明人研究了EP1受体拮抗剂，并确认具有磺酰胺结构的化合物，其中磺酰胺结构的氮原子被2-氟丙基基团，3-氟-2-甲基丙基基团或类似基团取代，具有强效的EP1受体拮抗作用，从而完成了本发明。本发明的磺酰胺化合物具有强效的EP1受体拮抗作用，可用作预防和/或治疗下尿路症状等剂。
• Sulfonamide compounds or salts thereof
  申请人：Astellas Pharma Inc.

  公开号：US08314240B2

  公开（公告）日：2012-11-20

  [Object] A compound which is useful as an EP1 receptor antagonist is provided. [Means for Solution] The present inventors investigated EP1 receptor antagonists, and confirmed that a compound having a sulfonamide structure, in which the nitrogen atom of the sulfonamide structure is substituted with 2-fluoropropyl group, 3-fluoro-2-methylpropyl group or the like, has a potent EP1 receptor antagonistic action, thereby completing the present invention. The sulfonamide compound of the present invention has a potent EP1 receptor antagonistic action and can be used as an agent for preventing and/or treating a lower urinary tract symptom or the like.

  【物品】提供一种作为EP1受体拮抗剂有用的化合物。 【解决方案】本发明人调查了EP1受体拮抗剂，并确认一种具有磺酰胺结构的化合物，其中磺酰胺结构的氮原子被取代为2-氟丙基基团、3-氟-2-甲基丙基基团或类似基团，具有有效的EP1受体拮抗作用，从而完成了本发明。本发明的磺酰胺化合物具有有效的EP1受体拮抗作用，可用作预防和/或治疗下尿路症状等的药物。
• PYRAZOLOQUINOLINE COMPOUND
  申请人：ASTELLAS PHARMA INC.

  公开号：US20130225553A1

  公开（公告）日：2013-08-29

  The present inventors have investigated a compound which has a PDE9-inhibiting action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, bladder/urethral diseases, and the like, and thus, have found that a pyrazoloquinoline compound has a PDE9-inhibiting action, thereby completing the present invention.

  本发明者已经研究了一种具有PDE9抑制作用的化合物，并且可用作治疗和/或预防储存功能障碍，排尿功能障碍，膀胱/尿道疾病等制剂的活性成分。因此，发现一种吡唑喹啉化合物具有PDE9抑制作用，从而完成了本发明。
• Pyrazoloquinoline compound
  申请人：Astellas Pharma Inc.

  公开号：US08822448B2

  公开（公告）日：2014-09-02

  The present inventors have investigated a compound which has a PDE9-inhibiting action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, bladder/urethral diseases, and the like, and thus, have found that a pyrazoloquinoline compound has a PDE9-inhibiting action, thereby completing the present invention.

  本发明者研究了一种具有PDE9抑制作用的化合物，可用作治疗和/或预防储存功能障碍、排尿功能障碍、膀胱/尿道疾病等药物的活性成分，并因此发现一种吡唑喹啉化合物具有PDE9抑制作用，从而完成了本发明。
• EP2305641
  申请人：——

  公开号：——

  公开（公告）日：——