2-(3-Vinyl-phenoxy)-tetrahydro-pyran | 133514-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(3-Vinyl-phenoxy)-tetrahydro-pyran
• 英文别名: 2-(3-Vinylphenoxy)tetrahydro-2H-pyran；2-(3-ethenylphenoxy)oxane
• CAS: 133514-07-5
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.269
• InChiKey: XIUHYXJWUMGXQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3-Vinyl-phenoxy)-tetrahydro-pyran 在 镍 9-borabicyclo[3.3.1]nonane dimer 、 Dowex 50WX₂-400 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 60.0 ℃ 、400.0 kPa 条件下， 反应 22.0h， 生成
  参考文献：
  名称：

  Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA

  摘要：

  Omega-conotoxin MVIIA, a highly potent antagonist of the N-type voltage sensitive calcium channel, has shown utility in several models of pain and ischemia. We report a series of three alkylphenyl ether based analogues which mimic three key amino acids of the toxin. Two of the compounds have been found to exhibit IC50 values of 2.7 and 3.3 mu M at the human N-type voltage sensitive calcium channel. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00699-x
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 間乙烯[苯]酚 在 对甲苯磺酸 作用下， 以 乙酸乙酯 为溶剂， 反应 1.0h， 生成 2-(3-Vinyl-phenoxy)-tetrahydro-pyran
  参考文献：
  名称：

  Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA

  摘要：

  Omega-conotoxin MVIIA, a highly potent antagonist of the N-type voltage sensitive calcium channel, has shown utility in several models of pain and ischemia. We report a series of three alkylphenyl ether based analogues which mimic three key amino acids of the toxin. Two of the compounds have been found to exhibit IC50 values of 2.7 and 3.3 mu M at the human N-type voltage sensitive calcium channel. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00699-x

文献信息

• BLOCK COPOLYMERS WITH HIGH FLORY-HUGGINS INTERACTION PARAMETERS FOR BLOCK COPOLYMER LITHOGRAPHY
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20150099109A1

  公开（公告）日：2015-04-09

  Block copolymers for use in block copolymer lithography, self-assembled films of the block copolymers and methods for polymerizing the block copolymers are provided. The block copolymers are characterized by high Flory-Huggins interaction parameters (χ). The block copolymers can be polymerized from protected hydroxystyrene monomers or from tert-butyl styrene and 2-vinylpyridine monomers.

  提供用于块共聚物光刻的块共聚物、块共聚物自组装薄膜以及聚合块共聚物的方法。这些块共聚物具有高Flory-Huggins相互作用参数(χ)。这些块共聚物可以从保护羟基苯乙烯单体或叔丁基苯乙烯和2-乙烯基吡啶单体聚合而成。
• ABA TRIBLOCK COPOLYMER AND PROCESS FOR PRODUCING THE SAME
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：EP2186837A1

  公开（公告）日：2010-05-19

  To provide a novel ABA-type triblock copolymer of vinyl ether series, comprising polyvinyl ether and an oxystyrene-series unit, and a process of producing the ABA-type copolymer at a series of steps. The invention relates to a novel ABA-type triblock copolymer comprising Segment A comprising an oxystyrene-series repeat unit (a) and Segment B comprising a vinyl ether-series repeat unit (b), in which the Segment A and the Segment B are bonded together with a single bond, and to a simple process of producing the same. The triblock copolymer can be produced at a series of steps in a simple manner, comprising living cationic polymerization of a vinyl ether-series monomer such as ethyl vinyl ether in the presence of a bifunctional initiator and a Lewis acid, and subsequently adding an oxystyrene-series monomer such as p-hydroxystyrene for living cationic polymerization.

  提供一种新型 ABA 型乙烯基醚系列三嵌段共聚物，该共聚物由聚乙烯醚和氧苯乙烯系列单元组成，并提供一种通过一系列步骤生产该 ABA 型共聚物的工艺。本发明涉及一种新颖的 ABA 型三嵌段共聚物，它由包含氧苯乙烯系列重复单元 （a）的段 A 和包含乙烯基醚系列重复单元（b）的段 B 组成，其中段 A 和段 B 以单 键结合在一起，本发明还涉及生产这种共聚物的简单工艺。三嵌段共聚物可以通过一系列简单步骤生产，包括在双官能团引发剂和路易斯酸存在下，乙烯基醚系列单体（如乙基乙烯基醚）的活阳离子聚合，然后加入氧基苯乙烯系列单体（如对羟基苯乙烯）进行活阳离子聚合。
• VINYL ETHER-BASED STAR POLYMER AND PROCESS FOR PRODUCTION THEREOF
  申请人：Maruzen Petrochemical CO., LTD.

  公开号：EP2412737A1

  公开（公告）日：2012-02-01

  Provided is a vinyl ether-based star polymer which has an arm including a vinyl ether polymer and an arm including an oxystyrene polymer. Also provided is a process for producing the star polymer, which can be continuously carried out in a series of steps. Said vinyl ether-based star polymer and process for producing the same are such that the polymer includes a core and polymer-chain arm portions extending from the core, in which an arm portion including vinyl ether repeating units and an arm portion including oxystyrene repeating units are provided.

  本发明提供了一种乙烯基醚基星形聚合物，其臂部包括乙烯基醚聚合物，臂部包括氧苯乙烯聚合物。此外，还提供了一种生产该星型聚合物的工艺，该工艺可通过一系列步骤连续进行。所述乙烯基醚基星形聚合物及其生产工艺使该聚合物包括一个核心和从核心延伸出来的聚合物链臂部分，其中臂部分包括乙烯基醚重复单元和臂部分包括氧苯乙烯重复单元。
• METALLIC NANOPARTICLE COMPOSITE AND METHOD FOR PRODUCING THE SAME
  申请人：Maruzen Petrochemical Co., Ltd.

  公开号：EP2669029A1

  公开（公告）日：2013-12-04

  Provided are a metal nanoparticle composite which exhibits excellent stability over time and retention stability and is useful as a raw material for a metal nanoparticle-dispersed film, a method for producing the composite, a metal nanoparticle dispersion liquid, a composition for forming a metal nanoparticle-dispersed film, and a metal nanoparticle-dispersed film. Disclosed is a metal nanoparticle composite comprising (A) a star-shaped polymer having a central core and arms bonded to the central core, the arms comprising a repeating unit represented by the following formula (1) and a repeating unit represented by the following formula (2); and (B) metal nanoparticles supported thereon: wherein in the formula (1), R1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; and in the formula (2), R2 represents a methyl group or an ethyl group; and k represents an integer from 1 to 10.

  本发明提供了一种金属纳米粒子复合材料，该复合材料具有优异的长期稳定性和保留稳定性，可用作金属纳米粒子分散膜的原料；还提供了一种生产该复合材料的方法、一种金属纳米粒子分散液、一种用于形成金属纳米粒子分散膜的组合物以及一种金属纳米粒子分散膜。公开了一种金属纳米粒子复合材料，包括(A)星形聚合物，该聚合物具有中心芯和与中心芯结合的臂，臂包括下式(1)代表的重复单元和下式(2)代表的重复单元；以及(B)支撑在其上的金属纳米粒子：其中，在式(1)中，R1代表氢原子或具有 1 至 4 个碳原子的烷基；在式(2)中，R2 代表甲基或乙基；以及 k 代表 1 至 10 的整数。
• PROTEIN ADSORPTION PREVENTING AGENT, PROTEIN ADSORPTION PREVENTING FILM, AND MEDICAL TOOL USING SAME
  申请人：Maruzen Petrochemical Co., Ltd.

  公开号：EP3647389A1

  公开（公告）日：2020-05-06

  To provide a protein adsorption preventing agent having an excellent film forming property and excellent water solubility, capable of easily coating various substrates, and having an excellent protein adsorption preventing property, and also to provide a protein adsorption preventing film using the protein adsorption preventing agent and a medical tool including the protein adsorption preventing film. A protein adsorption preventing agent containing an aqueous solvent and a polymer having at least a structural unit (A) represented by the following formula (1) (wherein R1 represents a methyl group or an ethyl group and n represents an integer of 1 to 10), and further containing a hydrophobic group, a protein adsorption preventing film using the protein adsorption preventing agent, and a medical tool including the protein adsorption preventing film.

  旨在提供一种成膜性和水溶性优异、能够方便地涂覆各种基材、具有优异的蛋白质吸附防止性能的蛋白质吸附防止剂，并提供一种使用该蛋白质吸附防止剂的蛋白质吸附防止膜和一种包括该蛋白质吸附防止膜的医疗工具。一种蛋白质吸附防止剂，含有水性溶剂和至少具有由下式（1）表示的结构单元（A）的聚合物（其中 R1 代表甲基或乙基，n 代表 1 至 10 的整数），并进一步含有疏水基团；一种使用该蛋白质吸附防止剂的蛋白质吸附防止膜；以及一种包括该蛋白质吸附防止膜的医疗工具。