3-[2-(2,4-Dichlorophenyl)-5-isopropyl-4-oxazolyl]-1-[3-methyl-4-(dimethylthiocarbamoyloxy)phenyl]propan-1-one | 500581-86-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[2-(2,4-Dichlorophenyl)-5-isopropyl-4-oxazolyl]-1-[3-methyl-4-(dimethylthiocarbamoyloxy)phenyl]propan-1-one
• 英文别名: O-[4-[3-[2-(2,4-dichlorophenyl)-5-propan-2-yl-1,3-oxazol-4-yl]propanoyl]-2-methylphenyl] N,N-dimethylcarbamothioate
• CAS: 500581-86-2
• 化学式: C₂₅H₂₆Cl₂N₂O₃S
• 分子量: 505.465
• InChiKey: BDFHXMQPKFTZQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  87.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[2-(2,4-Dichlorophenyl)-5-isopropyl-4-oxazolyl]-1-[3-methyl-4-(dimethylthiocarbamoyloxy)phenyl]propan-1-one 以 十四烷 为溶剂， 反应 8.0h， 以24%的产率得到3-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl]-1-[3-methyl-4-(dimethylcarbamoylsulfanyl)phenyl]propan-1-one
  参考文献：
  名称：

  ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR DELTA

  摘要：

  公开号：

  EP1424330B1
• 作为产物：
  描述：

  3-[2-(2,4-Dichlorophenyl)-5-isopropyl-4-oxazolyl]-1-(3-methyl-4-hydroxyphenyl)propan-1-one 、 二甲氨基硫代甲酰氯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 20.0h， 生成 3-[2-(2,4-Dichlorophenyl)-5-isopropyl-4-oxazolyl]-1-[3-methyl-4-(dimethylthiocarbamoyloxy)phenyl]propan-1-one
  参考文献：
  名称：

  ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR DELTA

  摘要：

  公开号：

  EP1424330B1

文献信息

• Activator of peroxisome proliferator-activated receptor
  申请人：Sakuma Shogo

  公开号：US20050054674A1

  公开（公告）日：2005-03-10

  A compound represented by the following general formula (I): (wherein R 1 represents phenyl, etc. which can have substituents selected from the group consisting of C 1-8 alkyl, C 1-8 alkyl having halogen, halogen, hydroxyl, etc.; R 2 represents C 1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C 1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R 3 , R 4 , and R 5 each represents hydrogen, C 1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R 6 and R 7 each represents hydrogen, C 1-8 alkyl, etc.; and R 8 represents hydrogen or C 1-8 alkyl; provided that at least one of R 3 , R 4 , and R 5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

  以下是一种由下列通式(I)表示的化合物：（其中R1代表苯基等，可以具有选择自C1-8烷基，具有卤素的C1-8烷基，卤素，羟基等的取代基; R2代表C1-8烷基等; A代表氧，硫等; X代表C1-8烷基链等; Y代表C（═O），CH═CH等; R3，R4和R5各代表氢，C1-8烷基等; B代表CH或氮; Z代表氧或硫; R6和R7各代表氢，C1-8烷基等; R8代表氢或C1-8烷基; 前提是R3、R4和R5中至少有一个不是氢）或该化合物的盐；以及包含该化合物或盐作为活性成分的PPAR-δ激动剂。
• Activator of peroxisome proliferator-activated receptor delta
  申请人：Sakuma Shogo

  公开号：US20080009525A1

  公开（公告）日：2008-01-10

  A compound represented by the following general formula (I): (wherein R 1 represents phenyl, etc. which can have substituents selected from the group consisting of C 1-8 alkyl, C 1-8 alkyl having halogen, halogen, hydroxyl, etc.; R 2 represents C 1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C 1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R 3 , R 4 , and R 5 each represents hydrogen, C 1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R 6 and R 7 each represents hydrogen, C 1-8 alkyl, etc.; and R 8 represents hydrogen or C 1-8 alkyl; provided that at least one of R 3 , R 4 , and R 5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

  以下是通式(I)所代表的化合物（其中R1代表苯基等，可具有选自C1-8烷基，带有卤素的C1-8烷基，卤素，羟基等取代基；R2代表C1-8烷基等；A代表氧，硫等；X代表C1-8亚烷基链等；Y代表C（═O），CH═CH等；R3，R4和R5各代表氢，C1-8烷基等；B代表CH或氮；Z代表氧或硫；R6和R7各代表氢，C1-8烷基等；R8代表氢或C1-8烷基；但至少其中之一的R3，R4和R5不是氢）或该化合物的盐；以及以该化合物或盐作为活性成分的PPAR-δ激动剂。
• Activator for peroxisome proliferator-activated receptor delta
  申请人：Sakuma Shogo

  公开号：US20080009631A1

  公开（公告）日：2008-01-10

  A compound represented by the following general formula (I): (wherein R 1 represents phenyl, etc. which can have substituents selected from the group consisting of C 1-8 alkyl, C 1-8 alkyl having halogen, halogen, hydroxyl, etc.; R 2 represents C 1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C 1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R 3 , R 4 , and R 5 each represents hydrogen, C 1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R 6 and R 7 each represents hydrogen, C 1-8 alkyl, etc.; and R 8 represents hydrogen or C 1-8 alkyl; provided that at least one of R 3 , R 4 , and R 5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

  以下是一种由下列通式（I）表示的化合物：（其中，R1代表苯基等，可以具有选自C1-8烷基，具有卤素的C1-8烷基，卤素，羟基等的取代基; R2代表C1-8烷基等; A代表氧，硫等; X代表C1-8烷基链等; Y代表C(═O)，CH═CH等; R3、R4和R5各代表氢，C1-8烷基等; B代表CH或氮; Z代表氧或硫; R6和R7各代表氢，C1-8烷基等; R8代表氢或C1-8烷基; 前提是R3、R4和R5中至少有一个不是氢）或该化合物的盐;以及包含该化合物或盐作为活性成分的PPAR-δ激动剂。
• US7265137B2
  申请人：——

  公开号：US7265137B2

  公开（公告）日：2007-09-04
• US7648999B2
  申请人：——

  公开号：US7648999B2

  公开（公告）日：2010-01-19