4,6-Dichloro-2,3-trimethylenequinoline | 40528-04-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4,6-Dichloro-2,3-trimethylenequinoline
• 英文别名: 7,9-dichloro-2,3-dihydro-1H-cyclopenta[b]quinoline；7,9-Dichlor-2,3-dihydro-1H-cyclopenta[b]chinolin；7,9-dichloro-2,3-dihydro-1H-cyclopenta[b]quinoline
• CAS: 40528-04-9
• 化学式: C₁₂H₉Cl₂N
• 分子量: 238.116
• InChiKey: DSAXMSKPQOLUOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4,6-Dichloro-2,3-trimethylenequinoline 在 氨 、 copper diacetate 作用下， 生成 7-chloro-2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine
  参考文献：
  名称：

  118.二氢-β-喹啉和四氢ac啶的一些氨基衍生物

  摘要：

  DOI：

  10.1039/jr9470000634
• 作为产物：
  描述：

  7-chloro-2,3-dihydro-1H-cyclopenta[b]quinolin-9-ol 在 三氯氧磷 作用下， 生成 4,6-Dichloro-2,3-trimethylenequinoline
  参考文献：
  名称：

  118.二氢-β-喹啉和四氢ac啶的一些氨基衍生物

  摘要：

  DOI：

  10.1039/jr9470000634

文献信息

• Design and synthesis of novel anti-Alzheimer’s agents: Acridine-chromenone and quinoline-chromenone hybrids
  作者：Zahra Najafi、Mina Saeedi、Mohammad Mahdavi、Reyhaneh Sabourian、Mahnaz Khanavi、Maliheh Barazandeh Tehrani、Farshad Homayouni Moghadam、Najmeh Edraki、Elahe Karimpor-Razkenari、Mohammad Sharifzadeh、Alireza Foroumadi、Abbas Shafiee、Tahmineh Akbarzadeh

  DOI：10.1016/j.bioorg.2016.06.001

  日期：2016.8

  A novel series of acridine-chromenone and quinoline-chromenone hybrids were designed, synthesized, and evaluated as anti-Alzheimer's agents. All synthesized compounds were evaluated as cholinesterases (ChEs) inhibitors and among them, 7-(4-(6-chloro-2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamino)phenoxy)-4-methyl-2 H-chromen-2-one (8e) exhibited the most potent anti-acetylcholinesterase (AChE) inhibitory

  设计，合成和评估了一系列新颖的a啶-色酮和喹啉-色酮杂化物，作为抗阿尔茨海默氏病的药物。所有合成的化合物均被评估为胆碱酯酶（ChEs）抑制剂，其中包括7-（4-（6-氯-2,3-二氢-1H-环戊[b]喹啉-9-基氨基）苯氧基）-4-甲基-与作为参考药物的利伐斯的明（IC50 =11.07μM）相比，2 H-chromen-2-one（8e）表现出最有效的抗乙酰胆碱酯酶（AChE）抑制活性（IC50 =16.17μM）。此外，还对化合物8e的β-分泌酶（BACE1）抑制和神经保护活性进行了评估，结果令人满意。
• HETEROCYCLIC COMPOUNDS AND THEIR USES
  申请人：Brown Matthew

  公开号：US20120094972A1

  公开（公告）日：2012-04-19

  Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

  含有替代双环杂芳基的化合物及其组合物，用于治疗一般性炎症、关节炎、风湿性疾病、骨关节炎、炎性肠道疾病、炎性眼部疾病、炎性或不稳定的膀胱疾病、牛皮癣、具有炎症成分的皮肤病、包括但不限于自身免疫性疾病，如系统性红斑狼疮（SLE）、重症肌无力、类风湿性关节炎、急性播散性脑脊髓炎、特发性血小板减少性紫癜、多发性硬化症、Sjogren综合征和自身免疫性溶血性贫血，包括所有过敏症形式的过敏症，本发明还提供了治疗介导、依赖或与p110活性相关的癌症的方法，包括但不限于白血病，如急性髓细胞白血病（AML）、骨髓增生异常综合征（MDS）、骨髓增殖性疾病（MPD）、慢性髓细胞白血病（CML）、T细胞急性淋巴细胞白血病（T-ALL）、B细胞急性淋巴细胞白血病（B-ALL）、非霍奇金淋巴瘤（NHL）、B细胞淋巴瘤和实体瘤，如乳腺癌。
• Heterocyclic compounds and their uses
  申请人：Brown Matthew

  公开号：US08765940B2

  公开（公告）日：2014-07-01

  Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

  含有替代双环杂环芳基的化合物及其组合物，用于治疗一般性炎症、关节炎、风湿性疾病、骨关节炎、炎症性肠病、炎症性眼疾、炎症性或不稳定的膀胱疾病、牛皮癣、含有炎症成分的皮肤疾病、慢性炎症性疾病，包括但不限于自身免疫性疾病，如系统性红斑狼疮（SLE）、重症肌无力、类风湿性关节炎、急性播散性脑脊髓炎、特发性血小板减少性紫癜、多发性硬化症、Sjogren综合症和自身免疫性溶血性贫血，包括所有形式的过敏反应。本发明还提供了用于治疗介导、依赖或与p110活性相关的癌症的方法，包括但不限于白血病，如急性髓系白血病（AML）、骨髓增生异常综合征（MDS）、骨髓增生性疾病（MPD）、慢性髓性白血病（CML）、T细胞急性淋巴细胞白血病（T-ALL）、B细胞急性淋巴细胞白血病（B-ALL）、非霍奇金淋巴瘤（NHL）、B细胞淋巴瘤和实体瘤，如乳腺癌。
• [EN] HETEROCYCLIC COMPOUNDS AND THEIR USES AS INHIBITORS OF PI3 K ACTIVITY<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS UTILISATIONS
  申请人：AMGEN INC

  公开号：WO2010151737A3

  公开（公告）日：2011-05-05
• Chadha et al., Journal Of Scientific and Industrial Research, 1951, vol. 10 B, p. 30
  作者：Chadha et al.

  DOI：——

  日期：——