2-(2,3-Difluoro-4-heptyl-6-methyl-phenyl)-[1,3,2]dioxaborolane | 601479-02-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,3-Difluoro-4-heptyl-6-methyl-phenyl)-[1,3,2]dioxaborolane
• 英文别名: 2-(2,3-Difluoro-4-heptyl-6-methylphenyl)-1,3,2-dioxaborolane
• CAS: 601479-02-1
• 化学式: C₁₆H₂₃BF₂O₂
• 分子量: 296.165
• InChiKey: LSTYRQZLTZHLAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.53
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-bromo-2-cyano-6-methyl-4-octyloxybenzene 、 2-(2,3-Difluoro-4-heptyl-6-methyl-phenyl)-[1,3,2]dioxaborolane 在 三苯基膦 、 cesium fluoride 、 palladium dichloride 作用下， 以 乙二醇二甲醚 为溶剂， 反应 48.0h， 以8.0 mg的产率得到2-(2,3-Difluoro-4-heptyl-6-methylphenyl)-3-methyl-5-octoxybenzonitrile
  参考文献：
  名称：

  Application of the Suzuki Reaction as the Key Step in the Synthesis of a Novel Atropisomeric Biphenyl Derivative for Use as a Liquid Crystal Dopant

  摘要：

  A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of the sterically hindered, electron poor boronate 22. Rigorously anhydrous conditions are therefore necessary to achieve the coupling.

  DOI：

  10.1021/jo034652s
• 作为产物：
  描述：

  2,3-difluoro-4-heptyl-6-methylanisole 在 palladium diacetate 吡啶 、 1,1'-双(二苯基膦)二茂铁 、 正丁基锂 、 甲酸 、 氢溴酸 、 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 17.0h， 生成 2-(2,3-Difluoro-4-heptyl-6-methyl-phenyl)-[1,3,2]dioxaborolane
  参考文献：
  名称：

  Application of the Suzuki Reaction as the Key Step in the Synthesis of a Novel Atropisomeric Biphenyl Derivative for Use as a Liquid Crystal Dopant

  摘要：

  A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of the sterically hindered, electron poor boronate 22. Rigorously anhydrous conditions are therefore necessary to achieve the coupling.

  DOI：

  10.1021/jo034652s

文献信息

• Application of the Suzuki Reaction as the Key Step in the Synthesis of a Novel Atropisomeric Biphenyl Derivative for Use as a Liquid Crystal Dopant
  作者：Andrew N. Cammidge、Karen V. L. Crépy

  DOI：10.1021/jo034652s

  日期：2003.8.1

  A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of the sterically hindered, electron poor boronate 22. Rigorously anhydrous conditions are therefore necessary to achieve the coupling.