N-hexylmethacrylamide | 87096-75-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-hexylmethacrylamide
• 英文别名: hexyl methacrylamide；N-hexyl-2-methylprop-2-enamide
• CAS: 87096-75-1
• 化学式: C₁₀H₁₉NO
• 分子量: 169.267
• InChiKey: FYCBGURDLIKBDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  氘代二甲亚砜 、 N-hexylmethacrylamide 在 ferrous(II) sulfate heptahydrate 、 叠氮基三甲基硅烷 、 双氧水 作用下， 反应 3.0h， 以64%的产率得到
  参考文献：
  名称：

  铁与叠氮基三甲基硅烷和二甲基亚砜介导的活性烯烃的叠氮基甲基化或叠氮基三甲基甲基化

  摘要：

  在温和的反应条件下，已实现了各种烯烃与叠氮基三甲基硅烷和二甲基亚砜的自由基叠氮甲基化，该方法有效地将常见且有价值的叠氮化物和甲基引入有机化合物。它提供了一种方便的方法来制备有机叠氮化物，可以轻松地将其转化为相关的胺衍生物和N杂环。提出了控制实验，例如捕获已开发系统的中间和克级反应以及反应产物的进一步转化。自由基参与反应过程。

  DOI：

  10.1002/adsc.201800078
• 作为产物：
  描述：

  正己胺 、 甲基丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以88 %的产率得到N-hexylmethacrylamide
  参考文献：
  名称：

  [EN] PRODRUG COPOLYMERS AND POLYMERIC MICELLES THEREOF FOR THE DELIVERY OF SHORT-CHAIN FATTY ACIDS, THE PROMOTION OF GUT HEALTH, AND THE TREATMENT OF IMMUNE AND/OR INFLAMMATORY CONDITIONS AND FOOD ALLERGY
  [FR] COPOLYMÈRES DE PROMÉDICAMENTS ET MICELLES POLYMÈRES DE CEUX-CI POUR L'ADMINISTRATION D'ACIDES GRAS À CHAÎNE COURTE, LA PROMOTION DE LA SANTÉ INTESTINALE ET LE TRAITEMENT D'ÉTATS IMMUNITAIRES ET/OU INFLAMMATOIRES ET D'ALLERGIE ALIMENTAIRE

  摘要：

  Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.

  公开号：

  WO2023081765A2

文献信息

• [EN] FORCE-RESPONSIVE POLYMERSOMES AND NANOREACTORS; PROCESSES UTILIZING THE SAME<br/>[FR] POLYMERSOMES ET NANORÉACTEURS SENSIBLES À LA FORCE; PROCÉDÉS LES UTILISANT
  申请人：ADOLPHE MERKLE INSTITUTE UNIV OF FRIBOURG

  公开号：WO2019034597A1

  公开（公告）日：2019-02-21

  The mechanically induced melting properties of DNA were employed to achieve force labile membranes is described. Nucleobase pairs were used as mechanophores. Adenine and thymine functionalized complementary amphiphilic block copolymers were self-assembled into polymersomes. The nucleobases formed hydrogen bonds which were disrupted upon force stimulation. The exposure of the disconnected nucleobases to the hydrophobic matrix of the membranes lead to a change of permeability which permitted the exchange of water-soluble molecules throughout the polymer matrix. Moreover, the encapsulation of horseradish peroxidase enabled the reaction of luminol with hydrogen peroxide to yield a luminescence producing species similar to the marine bioluminescence. Moreover, the same nano-reactors were employed to catalyze the formation of a polyacrylamide gel when force was applied. Insights into the change of permeability of supramolecular networks upon force are provided. These systems are useful for drug delivery, as nanoreactors and for the selective release of curing agents for 3D printing, or fragrances.

  DNA的机械诱导熔化特性被用来实现易受力破裂的膜。核碱基对被用作机械感受器。腺嘌呤和胸腺嘧啶功能化的互补两性分块共聚物自组装成聚合体囊。核碱基形成氢键，在受力刺激下被破坏。断开的核碱基暴露在膜的疏水基质中，导致渗透性的改变，从而允许水溶性分子在聚合物基质中交换。此外，封装辣根过氧化物酶使得辣根酰胺与过氧化氢反应产生类似海洋生物发光的发光物种。此外，当施加力时，相同的纳米反应器被用来催化聚丙烯酰胺凝胶的形成。提供了关于受力下超分子网络渗透性变化的见解。这些系统可用于药物传递、纳米反应器以及用于3D打印的固化剂或香料的选择性释放。
• LIQUID BISACYLPHOSPHINE OXIDE PHOTOINITIATOR
  申请人：BASF SE

  公开号：US20160168177A1

  公开（公告）日：2016-06-16

  A photoinitiator mixture comprising the components (a) a compound of the formula (I) wherein Ar and Ar 2 independently of each other are or naphthyl which is unsubstituted or substituted one or more times by R 1 , R 2 , R 3 or R′; R 1 and R 3 in-dependently of each other are C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halogen; R 2 is hydrogen, C 1 -C 4 alkyl, halogen, C 1 -C 4 alkoxy or C 2 -C 20 alkoxy which is interrupted by one or more O; Q is C 1 -C 4 alkylene; R 4 is methyl or ethyl; R′ and R″ independently of each other are hydrogen or PG-Y-R′″—X—; PG is a polymerizable group or methyl or ethyl; Y is a direct bond, O or S; X is a direct bond, O or S; R′″ is a direct bond, C 1 -C 20 alkylene or C 2 -C 20 alkylene which is interrupted by one or more O; (b) one or more compounds of the formula (II) wherein Ar 1 , Ar 2 and Q are as defined above, and R 5 is for example C 3 -C 30 alkyl which is unsubstituted or substituted and (c) optionally a compound of the formula (III) R 5 —OH   (III), wherein R 5 is as defined above; provides a liquid photointiator.

  一种光引发剂混合物，包括组分(a) 公式(I)的化合物，其中Ar和Ar2独立地是苯基或萘基，未取代或被R1、R2、R3或R′取代一次或多次；R1和R3独立地是C1-C4烷基、C1-C4烷氧基或卤素；R2是氢、C1-C4烷基、卤素、C1-C4烷氧基或被一个或多个O打断的C2-C20烷氧基；Q是C1-C4烷基；R4是甲基或乙基；R′和R″独立地是氢或PG-Y-R′″—X—；PG是可聚合基团或甲基或乙基；Y是直键、O或S；X是直键、O或S；R′″是直键、C1-C20烷基或被一个或多个O打断的C2-C20烷基；(b) 一个或多个公式(II)的化合物，其中Ar1、Ar2和Q如上定义，R5例如是未取代或取代的C3-C30烷基；(c) 可选地一个公式(III)的化合物R5—OH (III)，其中R5如上定义；提供一种液体光引发剂。
• [EN] NOVEL PHOTO-INITIATORS AND THEIR APPLICATION<br/>[FR] NOUVEAUX PHOTO-INITIATEURS ET LEUR UTILISATION
  申请人：ETH ZUERICH

  公开号：WO2019175112A1

  公开（公告）日：2019-09-19

  The present invention relates to novel bisacylphosphinic acids, salts and derivatives thereof as well as their use as photo-initiators with superior water solubility and photo-activity. The invention further encompasses versatile processes for the preparation of the aforementioned compounds.

  本发明涉及新型双酰基膦酸、其盐和衍生物，以及它们作为具有优越水溶性和光活性的光引发剂的用途。本发明还涵盖了用于制备上述化合物的多功能过程。
• [EN] NOVEL VINYL PHOSPHINES AND PHOTO-INITIATORS OBTAINABLE THEREFROM<br/>[FR] NOUVELLES PHOSPHINES DE VINYLE ET PHOTO-INITIATEURS POUVANT ÊTRE OBTENUS À PARTIR DE CELLES-CI
  申请人：ETH ZUERICH

  公开号：WO2019175319A1

  公开（公告）日：2019-09-19

  The present invention relates to a highly efficient process to prepare alkyl and vinyl phosphines which are useful as starting materials for novel bisacylphosphine oxides, bisacylphosphinic acids, salts, and derivatives thereof each bearing a vinyl functionality bound to the phosphorous atom as well as a versatile process for the preparation of the latter.

  本发明涉及一种高效的工艺，用于制备烷基和乙烯基膦，这些膦可作为新型双酰膦氧化物、双酰膦酸、盐和衍生物的起始材料，每种衍生物都带有与磷原子结合的乙烯基官能团，以及用于制备后者的多功能工艺。
• [EN] DERIVATIVES OF BISACYLPHOSPHINIC ACID, THEIR PREPARATION AND USE AS PHOTOINITIATORS<br/>[FR] DÉRIVÉS D'ACIDE BISACYLPHOSPHINIQUE, LEUR PRÉPARATION ET LEUR UTILISATION EN TANT QUE PHOTO-INITIATEURS
  申请人：BASF SE

  公开号：WO2014095724A1

  公开（公告）日：2014-06-26

  Bisacylphosphine oxide or bisacylphosphine sulfide compounds of formula (I) or (II) wherein R1, R2, R3, R1a, R2a and R3a independently of each other are C1-C4alkyl, C1-C4alkoxy or halogen; X is O, NR5 or S; or, if R4 is CI, F or Br, X is a direct bond; Y is O or S; n is 1 or 2; R4, if n is 1, for example is hydrogen, (CO)R6, (CO)OR6, (CO)NR5R6, (SO2)-R6, C1-C28alkyl, R4, if n = 2, is for example C1-C18alkylene; R5 is for example hydrogen, or C1-C12alkyl; R6 is for example C1-C12alkyl; R7, R8 and R9 independently of each other for example are C1-C4alkyl; R10 is for example C2-C18alkylene; X1 is O or S; m is 1, 2 or 3; Q represents one or two inorganic or organic cations with a charge of m+; are suitable photoinitiators, available by a claimed process.

  双酰基膦氧化物或双酰基膦硫化物化合物的结构式（I）或（II），其中R1、R2、R3、R1a、R2a和R3a彼此独立地是C1-C4烷基、C1-C4烷氧基或卤素；X为O、NR5或S；或者，如果R4是CI、F或Br，则X为直接键；Y为O或S；n为1或2；例如，如果n为1，则R4为氢、（CO）R6、（CO）OR6、（CO）NR5R6、（SO2）-R6、C1-C28烷基；如果n=2，则R4为例如C1-C18烷基；例如，R5为氢或C1-C12烷基；例如，R6为C1-C12烷基；例如，R7、R8和R9彼此独立地为C1-C4烷基；例如，R10为C2-C18烷基；X1为O或S；m为1、2或3；Q代表带有m+电荷的一个或两个无机或有机阳离子，是通过声明的过程得到的合适的光引发剂。