1-(2,4-Difluorophenyl)-6-fluoro-7-methyl-4-oxoquinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2,4-Difluorophenyl)-6-fluoro-7-methyl-4-oxoquinoline-3-carboxylic acid
• 化学式: C₁₇H₁₀F₃NO₃
• 分子量: 333.26
• InChiKey: ICCURRHDSSOCKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBTITUENT AT 14-POSITION
  申请人：Fukuda Yasumichi

  公开号：US20100197909A1

  公开（公告）日：2010-08-05

  To provide a novel mutilin derivative having a substitution at the 14-position, which is a novel mutilin analogue exhibiting a potent and broad antimicrobial action against Gram-positive bacteria and Gram-negative bacteria including various drug-resistant bacteria, and which is expected to be useful as an agent for treating infectious diseases. A mutilin derivative represented by the following general formula (1): or a pharmaceutically acceptable addition salt thereof.

  提供一种在14位点具有取代基的新型多黏菌素衍生物，该新型多黏菌素类似物表现出强大而广泛的抗菌活性，可对抗革兰氏阳性菌和革兰氏阴性菌，包括各种耐药菌，并且预计可用作治疗传染病的药物。该多黏菌素衍生物由以下一般式（1）表示：或其药学上可接受的加盐物。
• BORON CONTAINING SMALL MOLECULES
  申请人：HERNANDEZ Vincent S.

  公开号：US20110124597A1

  公开（公告）日：2011-05-26

  This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

  这项发明提供了多种新型化合物，用于治疗细菌感染，包括含有这些化合物的药物组合物，以及这些化合物与至少一种其他治疗有效剂的组合。
• MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBSTITUENT AT 14-POSITION
  申请人：Kyorin Pharmaceutical Co., Ltd.

  公开号：EP2149571A1

  公开（公告）日：2010-02-03

  To provide a novel mutilin derivative having a substitution at the 14-position, which is a novel mutilin analogue exhibiting a potent and broad antimicrobial action against Gram-positive bacteria and Gram-negative bacteria including various drug-resistant bacteria, and which is expected to be useful as an agent for treating infectious diseases. A mutilin derivative represented by the following general formula (1): or a pharmaceutically acceptable addition salt thereof.

  提供一种在 14 位上具有取代位的新型 mutilin 衍生物，它是一种新型 mutilin 类似物，对革兰氏阳性菌和革兰氏阴性菌（包括各种耐药菌）具有强效和广泛的抗菌作用，有望用作治疗传染性疾病的药物。一种由以下通式（1）代表的 mutilin 衍生物： 或其药学上可接受的加成盐。
• US8222407B2
  申请人：——

  公开号：US8222407B2

  公开（公告）日：2012-07-17