5-(chloromethyl)-2-methoxy-3-(trifluoromethyl)pyridine | 1206124-61-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(chloromethyl)-2-methoxy-3-(trifluoromethyl)pyridine
• CAS: 1206124-61-9
• 化学式: C₈H₇ClF₃NO
• 分子量: 225.598
• InChiKey: PSOZLNFODNJKCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(chloromethyl)-2-methoxy-3-(trifluoromethyl)pyridine 在 三氯氧磷 作用下， 生成 6-chloro-5-trifluoromethylpyridin-3-ylmethyl chloride
  参考文献：
  名称：

  [EN] SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
  [FR] DÉRIVÉS DE L'ACIDE 1,2,3,4-TÉTRAHYDROCYCLOPENTA[B]INDOL-3-YLE ACÉTIQUE SUBSTITUÉ UTILISÉS DANS LE TRAITEMENT DES MALADIES AUTO-IMMUNES ET INFLAMMATOIRES

  摘要：

  本发明涉及某些替代的1,2,3,4-四氢环戊基吲哚-3-基乙酸衍生物的化合物（Ia）及其药用盐，这些化合物展示出有用的药理特性，例如作为S1P1受体的激动剂。本发明还提供了含有该发明化合物的药物组合物，以及使用该发明化合物和组合物治疗S1P1受体相关疾病的方法，例如银屑病、类风湿关节炎、克罗恩病、移植排斥、多发性硬化症、系统性红斑狼疮、溃疡性结肠炎、I型糖尿病、痤疮、微生物感染或疾病以及病毒感染或疾病。

  公开号：

  WO2010011316A1

文献信息

• SUBSTITUTED 1,2,3,4-TETRAHYDROCYCLOPENTA[B]INDOL-3-YL)ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
  申请人：Jones Robert M.

  公开号：US20110130409A1

  公开（公告）日：2011-06-02

  The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.

  本发明涉及某些取代的1,2,3,4-四氢环戊[b]吲哚-3-基乙酸衍生物（Ia式）及其药学上可接受的盐，其具有有用的药理特性，例如作为S1P1受体激动剂。本发明还提供了含有该发明化合物的药物组合物，以及使用该化合物和组合物治疗S1P1受体相关疾病的方法，例如牛皮癣、类风湿性关节炎、克隆病、移植排斥、多发性硬化症、系统性红斑狼疮、溃疡性结肠炎、1型糖尿病、痤疮、微生物感染或疾病和病毒感染或疾病。
• SUBSTITUTED 1,2,3,4-TETRAHYDROCYCLOPENTA[b]INDOL-3-YL)ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
  申请人：Arena Pharmaceuticals, Inc.

  公开号：US20140038987A1

  公开（公告）日：2014-02-06

  The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.

  本发明涉及某些取代的1,2,3,4-四氢环戊[b]吲哚-3-基)乙酸衍生物(Ia式)及其药学上可接受的盐，这些衍生物具有有用的药理学特性，例如作为S1P1受体的激动剂。本发明还提供了含有本发明化合物的药物组合物，并且提供了使用本发明化合物和组合物治疗S1P1受体相关疾病的方法，例如牛皮癣、类风湿性关节炎、克罗恩病、移植排斥、多发性硬化症、全身性红斑狼疮、溃疡性结肠炎、1型糖尿病、痤疮、微生物感染或疾病和病毒感染或疾病。
• Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
  申请人：Jones Robert M

  公开号：US08580841B2

  公开（公告）日：2013-11-12

  The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia): and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.

  本发明涉及某些取代的1,2,3,4-四氢环戊[b]吲哚-3-基乙酸衍生物（Ia式）及其药学上可接受的盐，该衍生物具有有用的药理学特性，例如作为S1P1受体的激动剂。本发明还提供了含有该发明化合物的药物组合物，以及使用该化合物和组合物治疗S1P1受体相关疾病的方法，例如银屑病、类风湿性关节炎、克隆病、移植排斥、多发性硬化症、系统性红斑狼疮、溃疡性结肠炎、I型糖尿病、痤疮、微生物感染或疾病以及病毒感染或疾病。
• [EN] MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO<br/>[FR] MODULATEURS DU RÉCEPTEUR SPHINGOSINE-1-PHOSPHATE (S1P) UTILES POUR LE TRAITEMENT DE TROUBLES ASSOCIÉS À CEUX-CI
  申请人：ARENA PHARM INC

  公开号：WO2011005295A8

  公开（公告）日：2012-09-20
• SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP2326621A1

  公开（公告）日：2011-06-01