(E)-3-(2-Hydroxy-phenyl)-2-methyl-acrylic acid 4-carbamimidoyl-phenyl ester | 112021-85-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(2-Hydroxy-phenyl)-2-methyl-acrylic acid 4-carbamimidoyl-phenyl ester
• 英文别名: (4-carbamimidoylphenyl) (E)-3-(2-hydroxyphenyl)-2-methylprop-2-enoate
• CAS: 112021-85-9
• 化学式: C₁₇H₁₆N₂O₃
• 分子量: 296.326
• InChiKey: IDIIUROMONKXEC-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  96.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-3-(2-Hydroxy-phenyl)-2-methyl-acrylic acid 4-carbamimidoyl-phenyl ester 以 乙醇 为溶剂， 以1192 %的产率得到3-甲基氧杂萘邻酮
  参考文献：
  名称：

  Photochemical activation of acylated .alpha.-thrombin

  摘要：

  DOI：

  10.1021/ja00238a062
• 作为产物：
  描述：

  ethyl o-hydroxy-α-methylcinnamate 在 水 、 N,N'-二环己基碳二亚胺 作用下， 生成 (E)-3-(2-Hydroxy-phenyl)-2-methyl-acrylic acid 4-carbamimidoyl-phenyl ester
  参考文献：
  名称：

  Photochemical activation of acylated .alpha.-thrombin

  摘要：

  DOI：

  10.1021/ja00238a062

文献信息

• LIGHT ACTIVATED ACYL-ENZYMES
  申请人：DUKE UNIVERSITY

  公开号：EP0489836A1

  公开（公告）日：1992-06-17
• EP0489836A4
  申请人：——

  公开号：EP0489836A4

  公开（公告）日：1993-05-26
• Systems and devices for photoablation
  申请人：Stolen Craig

  公开号：US20090054883A1

  公开（公告）日：2009-02-26

  The invention provides a catheter for optical ablation of tissue in a living body, the catheter including: a distal end; a proximal end; an elongate catheter body coupled between the distal end and the proximal end; a light emission device at the distal end and configured to emit an ablation light having characteristics selected to regulate an optically regulatable transcription control element operably linked to a nucleic acid sequence for a gene product, the expression of which gene product in cells directly or indirectly kills cells; and a projection control mechanism coupled to the light emission device and configured to control an effectively illuminated area where the optically regulatable transcription control element is effectively regulatable by the ablation light projected from the light emission device. Also provided is a system which includes the catheter, and methods to prevent, inhibit or treat AF which employ an expression cassette and/or one or more selected wavelengths of light.
• US5114851A
  申请人：——

  公开号：US5114851A

  公开（公告）日：1992-05-19
• US5218137A
  申请人：——

  公开号：US5218137A

  公开（公告）日：1993-06-08