1,7-dioxo-1,4,7,10-tetrahydro-quino[8,7-h]quinoline-3,9-dicarboxylic acid dimethyl ester | 52296-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,7-dioxo-1,4,7,10-tetrahydro-quino[8,7-h]quinoline-3,9-dicarboxylic acid dimethyl ester
• 英文别名: Dimethyl 1,4,7,10-Tetrahydro-1,7-dioxoquino-[8,7-h]quinoline-3,9-dicarboxylate；Dimethyl 1,7-dioxo-1,4,7,10-tetrahydroquino[8,7-h]quinoline-3,9-dicarboxylate；dimethyl 1,7-dioxo-4,10-dihydroquinolino[8,7-h]quinoline-3,9-dicarboxylate
• CAS: 52296-34-1
• 化学式: C₂₀H₁₄N₂O₆
• 分子量: 378.341
• InChiKey: OYDATSSHXGPEOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,7-dioxo-1,4,7,10-tetrahydro-quino[8,7-h]quinoline-3,9-dicarboxylic acid dimethyl ester 以 sodium hydroxide 为溶剂， 生成 disodium 1,4,7,10-tetrahydro-1,7-dioxoquino[8,7-h]quinoline-3,9-dicarboxylate
  参考文献：
  名称：

  Compounds, compositions and methods of use

  摘要：

  式为##SPC1##的化合物对于预防敏感的人和动物的过敏和免疫反应非常有用，这些反应是由抗原或非抗原介导的。同时，本发明还提供了这些化合物与药物载体配制的组合物及使用这些组合物的方法。

  公开号：

  US03953598A1
• 作为产物：
  描述：

  1,5-萘二胺 在 四磷十氧化物 作用下， 以 甲醇 为溶剂， 生成 1,7-dioxo-1,4,7,10-tetrahydro-quino[8,7-h]quinoline-3,9-dicarboxylic acid dimethyl ester
  参考文献：
  名称：

  A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles

  摘要：

  The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation.

  DOI：

  10.1021/jo070181o

文献信息

• [EN] ELECTRONIC DEVICE INCLUDING A DIAZACHRYSENE DERIVATIVE<br/>[FR] DISPOSITIF ÉLECTRONIQUE COMPRENANT UN DÉRIVÉ DE DIAZACHRYSÈNE
  申请人：DU PONT

  公开号：WO2014130597A1

  公开（公告）日：2014-08-28

  There is provided a compound having Formula I. In Formula I: R1-R10 are the same or different and can be H, D, alkyl, aryl, alkoxy, aryloxy, silyl, or deuterated analogs of alkyl, aryl, alkoxy, aryloxy and silyl, where adjacent R groups can be joined together to form a ring; and all other sites are H or D. Additionally in Formula I:(i) at least one of R1-R3 and at least one of R4-R6 is alkyl, alkoxy, silyl, or a deuterated analog, and (ii) at least one of R1-R3 and at least one of R4-R6 is aryl, aryloxy, or a deuterated analog.

  提供一种具有化学式I的化合物。在化学式I中：R1-R10相同或不同，可以是H、D、烷基、芳基、烷氧基、芳氧基、硅基，或者是烷基、芳基、烷氧基、芳氧基和硅基的氘代物，其中相邻的R基可以连接在一起形成环；其他所有位置为H或D。此外，在化学式I中：(i) R1-R3中至少有一个和R4-R6中至少有一个是烷基、烷氧基、硅基或氘代物，以及(ii) R1-R3中至少有一个和R4-R6中至少有一个是芳基、芳氧基或氘代物。
• ELECTRONIC DEVICE INCLUDING A DIAZACHRYSENE DERIVATIVE
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：US20150380664A1

  公开（公告）日：2015-12-31

  There is provided a compound having Formula I In Formula I: R 1 -R 10 are the same or different and can be H, D, alkyl, aryl, alkoxy, aryloxy, silyl, or deuterated analogs of alkyl, aryl, alkoxy, aryloxy and silyl, where adjacent R groups can be joined together to form a ring; and all other sites are H or D. Additionally in Formula I: (i) at least one of R 1 -R 3 and at least one of R 4 -R 6 is alkyl, alkoxy, silyl, or a deuterated analog, and (ii) at least one of R 1 -R 3 and at least one of R 4 -R 6 is aryl, aryloxy, or a deuterated analog.

  提供了一种化合物，其化学式为I。在化学式I中：R1-R10相同或不同，可以是H，D，烷基，芳基，烷氧基，芳氧基，硅烷基或烷基，芳基，烷氧基，芳氧基和硅烷基的氘代物，其中相邻的R基可以连接在一起形成环；其余位置为H或D。此外，在化学式I中：（i）至少有R1-R3中的一个和R4-R6中的至少一个是烷基，烷氧基，硅烷基或氘代物，（ii）至少有R1-R3中的一个和R4-R6中的至少一个是芳基，芳氧基或氘代物。
• US3953598A
  申请人：——

  公开号：US3953598A

  公开（公告）日：1976-04-27
• US9748497B2
  申请人：——

  公开号：US9748497B2

  公开（公告）日：2017-08-29
• A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles
  作者：Daniel Zewge、Cheng-yi Chen、Curtis Deer、Peter G. Dormer、Dave L. Hughes

  DOI：10.1021/jo070181o

  日期：2007.5.1

  The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation.