N-丹磺酰氮丙啶 | 51908-46-4

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 芳香烃
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-丹磺酰氮丙啶
• 中文别名: N-丹磺酰-1-氮杂环丙烷
• 英文名称: N-dansylaziridine
• 英文别名: Dansylaziridine；5-(aziridin-1-ylsulfonyl)-N,N-dimethylnaphthalen-1-amine
• CAS: 51908-46-4
• 化学式: C₁₄H₁₆N₂O₂S
• 分子量: 276.359
• InChiKey: LSKWDEYBJACPBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  48.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R40
• 海关编码：
  2933990090
• 安全说明：
  S22,S36

SDS

Name:	Dansyl Aziridine Material Safety Data Sheet
Synonym:	None
CAS:	51908-46-4

Section 1 - Chemical Product MSDS Name:Dansyl Aziridine Material Safety Data Sheet
Synonym:None

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
51908-46-4	Dansyl Aziridine	100 %	257-508-2

Hazard Symbols: XN
Risk Phrases: 20/21/22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.Cancer suspect agent.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
May cause cancer according to animal studies.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Substance is nonflammable; use agent most appropriate to extinguish surrounding fire.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Reduce airborne dust and prevent scattering by moistening with water. Clean up spills immediately, observing precautions in the Protective Equipment section.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 51908-46-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: pale yellow
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 90 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Insoluble in water.
Specific Gravity/Density: Not available.
Molecular Formula: C14H16N2O2S
Molecular Weight: 276.1842

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizers.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 51908-46-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Dansyl Aziridine - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 25 Avoid contact with eyes.
WGK (Water Danger/Protection)
CAS# 51908-46-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 51908-46-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 51908-46-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N-丹磺酰氮丙啶 在 盐酸 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  Synthesis and characterization of the zinc(ii)-fluorophore, 5-dimethylaminonaphthalene-1-sulfonic acid [2-(1,5,9-triazacyclododec-1-yl)ethyl]amide and its zinc(ii) complex

  摘要：

  合成并表征了一种新的锌(II)-荧光团5-二甲氨基萘-1-磺酸[2-(1,5,9-三氮杂环十二碳-1-基)乙基]酰胺(HL)。分光光度法和电位 pH 滴定研究表明，在 25 °C 下，与 I 形成 1 ∶ 1 锌 (II) 络合，稳定常数 K(ZnL) 为 101.3 (= [ZnL]aH+/[Zn2+][HL]) = 0.10 (NaCl) 在水溶液中，其中 L 是丹磺酰胺去质子化配体。在 pH 7.8、25 °C 的水溶液中，ZnL 在 538 nm（激发波长 320 nm）处的荧光强度是配体（HL·H+ 形式）的 5.2 倍。 = 0.10（氯化钠）。锌(II)络合物[ZnL(ClO4)·EtOH]的X射线晶体分析表明，锌(II)是具有大环三胺的三个氮原子的四配位锌(II)， 丹磺酰胺 N− 阴离子。

  DOI：

  10.1039/b110878f
• 作为产物：
  描述：

  乙烯亚胺 、 丹酰氯 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 以86%的产率得到N-丹磺酰氮丙啶
  参考文献：
  名称：

  Xue; Bradshaw; Chiara, Synlett, 2000, # 8, p. 1181 - 1183

  摘要：

  DOI：

文献信息

• Synthesis of diazadibenzo-18-crown-6 ligands with appended chromophoric and fluorophoric groups as potential metal ion chemosensors
  作者：Guo-Ping Xue、Paul B. Savage、Krzysztof E. Krakowiak、Reed M. Izatt、Jerald S. Bradshaw

  DOI：10.1002/jhet.5570380631

  日期：2001.11

  Six new diazadibenzo-18-crown-6 ligands substituted with two each of 8-hydroxyquinoline (7), 8-amino-quinoline (attached through its C-2 or C-7 position) (12 and 13), 8-methoxyquinoline (18), 5-chloro-8-methoxyquinoline (19), and dansylamidoethyl (21) side arms were synthesized as potential metal ion chemosensors and potential reagents for the selective extraction of certain metal ions from aqueous

  六个新的重氮二苯并18-18冠-6配体分别被8-羟基喹啉（7），8-氨基喹啉（通过其C-2或C-7位置连接）（12和13），8-甲氧基喹啉中的两个取代18）合成了5-氯-8-甲氧基喹啉（19）和dansylamidoethyl（21）侧臂作为潜在的金属离子化学传感器和潜在的试剂，用于从水溶液中选择性提取某些金属离子。配体7，12，13，18，和19，通过二苯并-18-冠-6（还原胺化合成5）及相应的quinolinecarboxaldehydes。双（丹西酰胺基乙基）取代的配体21通过用N-丹磺酰氮丙啶（20）处理二氮杂皇冠醚5来合成。
• Light-Emitting Molecular Machines: pH-Induced Intramolecular Motions in a Fluorescent Nickel(II) Scorpionate Complex
  作者：Luigi Fabbrizzi、Francesco Foti、Maurizio Licchelli、Paola M. Maccarini、Donatella Sacchi、Michele Zema

  DOI：10.1002/1521-3765(20021104)8:21<4965::aid-chem4965>3.0.co;2-x

  日期：2002.11.4

  the corresponding nickel(II) complex, binding of the pendant arm to the metal is pH controlled. In particular, at pH 4.3, the sulfonamide group deprotonates and coordinates the NiII center, giving rise to a complex of trigonal bipyramidal stereochemistry, as shown by X-ray diffraction studies performed on the crystalline complex salt. At pH 7.5, an OH- ion binds the metal and a six-coordinate species

  已经合成了具有含丹磺酰胺基团的侧链的类环素大环。在相应的镍（II）络合物中，侧链与金属的结合受pH控制。特别地，在pH 4.3下，磺酰胺基团去质子化并配位NiII中心，从而产生了三角双锥体立体化学的络合物，如对结晶络合物盐进行的X射线衍射研究所示。在pH 7.5时，OH离子与金属结合，形成六配位物质。侧链上丹磺酰基亚基的发射性质发生变化，表明悬垂臂与NiII中心的结合/脱离。当侧链未配位时，该侧链的荧光较高；而当磺酰胺基团与金属结合时，该侧链的荧光较低。
• Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
  申请人：——

  公开号：US20020055133A1

  公开（公告）日：2002-05-09

  The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying the optimum probe attachment site. Biosensors are provided having environmentally sensitive dyes that can locate specific biomolecules within living cells and detect chemical and physiological changes in those biomolecules as the living cell is moving, metabolizing and reacting to its environment. Methods are included for detecting GTP activation of a Rho GTPase protein using polypeptide biosensors. When the biosensor binds GTP-activated Rho GTPase protein, the environmentally sensitive dye emits a signal of a different lifetime, intensity or wavelength than when not bound. New fluorophores whose fluorescence responds to environmental changes are also provided that have improved detection and attachment properties, and that can be used in living cells, or in vitro.

  该发明提供了具有保护功能基团的肽合成物，用于连接所需的基团（例如功能分子或探针）。还提供了从这些合成物制备的肽共轭物，并提供了用于鉴定最佳探针连接位点的合成物和共轭物制备方法。提供了生物传感器，其中包含可以定位活细胞内特定生物分子并检测这些生物分子在细胞移动、代谢和对其环境反应时的化学和生理变化的环境敏感染料。还包括用于使用多肽生物传感器检测Rho GTPase蛋白的GTP激活的方法。当生物传感器结合GTP激活的Rho GTPase蛋白时，环境敏感染料发出与未结合时不同寿命、强度或波长的信号。还提供了对环境变化响应的新荧光分子，具有改进的检测和连接特性，并可用于活细胞或体外。
• ALIGNMENT OF NANOMATERIALS AND MICROMATERIALS
  申请人：Lu Yi

  公开号：US20140024818A1

  公开（公告）日：2014-01-23

  The present invention provides a method for preparing a nanoassembly that includes the step of reacting the assembly template with at least one nanomaterial to form the nanoassembly using a bifunctional linker.

  本发明提供了一种制备纳米组装体的方法，其中包括使用双功能连接剂将组装模板与至少一种纳米材料反应以形成纳米组装体的步骤。
• Liquid ink and recording apparatus
  申请人：Toshiba Tec Kabushiki Kaisha

  公开号：EP1357159A2

  公开（公告）日：2003-10-29

  There is disclosed a liquid ink comprising a photo acid generating agent that generates an acid upon irradiation with light, a coloring component, and at least one kind of a solvent that is polymerized in the presence of an acid. It is preferable that the amount of the photo acid generating agent contained in the liquid ink falls within a range of between 1 part by weight and 10 parts by weight relative to 100 parts by weight of the solvent, the coloring component consists of a pigment, and the solvent contains at least 50 parts by weight of an acid polymerizable compound, the acid polymerizing compound polymerizing in the presence of the acid, having an alicyclic skeleton and/or an aliphatic skeleton having a viscosity of 50 mPa·s or less and a boiling point of 150°C or more under room temperature and atmospheric pressure.

  本发明公开了一种液体油墨，该油墨由在光照射下产生酸的光酸生成剂、着色成分和至少一种在酸存在下聚合的溶剂组成。相对于 100 重量份的溶剂，液体油墨中所含的光酸生成剂的量最好在 1 重量份到 10 重量份之间，着色成分由颜料组成、溶剂中含有至少 50 份（重量）的可酸聚合化合物，该酸聚合化合物在酸存在下聚合，具有脂环族骨架和/或脂肪族骨架，在室温和常压下粘度为 50 mPa-s 或更低，沸点为 150°C 或更高。