Diethyl-(3-methyl-buten-(3)-in-(1)-yl)-aluminiumm | 5075-25-2

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: Diethyl-(3-methyl-buten-(3)-in-(1)-yl)-aluminiumm
• CAS: 5075-25-2
• 化学式: C₉H₁₅Al
• 分子量: 150.2
• InChiKey: NQVVSJJXEXLHGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  Diethyl-(3-methyl-buten-(3)-in-(1)-yl)-aluminiumm 、 在 三氟化硼乙醚 作用下， 以 乙醚 、 正己烷 、 二氯甲烷 、 甲苯 为溶剂， 以69%的产率得到(2R,4R,6S)-2-tert-Butyl-4-hexyl-6-(3-methyl-but-3-en-1-ynyl)-[1,3]dioxane
  参考文献：
  名称：

  Coupling of alkynyl organometallics with 4-acetoxy-1,3-dioxanes: Synthesis of propargylic and allylic anti-1,3-diols

  摘要：

  Alkynyl diethylalanes and stannanes couple with 4-acetoxy-1,3-dioxane 1 in the presence of BF3 . OEt2 to give acetal protected propargylic anti-1,3-diols 2 in high yield, with exquisite diastereoselectivity and little acetal epimerization. These propargylic dioxanes 2 are useful intermediates for further diastereoselective reactions. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00512-7

文献信息

• Coupling of alkynyl organometallics with 4-acetoxy-1,3-dioxanes: Synthesis of propargylic and allylic anti-1,3-diols
  作者：Noel A. Powell、Scott D. Rychnovsky

  DOI：10.1016/s0040-4039(98)00512-7

  日期：1998.5

  Alkynyl diethylalanes and stannanes couple with 4-acetoxy-1,3-dioxane 1 in the presence of BF3 . OEt2 to give acetal protected propargylic anti-1,3-diols 2 in high yield, with exquisite diastereoselectivity and little acetal epimerization. These propargylic dioxanes 2 are useful intermediates for further diastereoselective reactions. (C) 1998 Elsevier Science Ltd. All rights reserved.