2-(4-Chlorophenyl)sulfanyl-1-(4-phenylphenyl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-Chlorophenyl)sulfanyl-1-(4-phenylphenyl)ethanone
• 化学式: C₂₀H₁₅ClOS
• 分子量: 338.857
• InChiKey: CTDACTDVGRMKHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-叠氮基-4-(三氟甲基)苯 、 2-(4-Chlorophenyl)sulfanyl-1-(4-phenylphenyl)ethanone 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二甲基亚砜 为溶剂， 以85%的产率得到5-([1,1'-biphenyl]-4-yl)-4-((4-chlorophenyl)thio)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazole
  参考文献：
  名称：

  An Organocatalytic Regiospecific Synthesis of 1,5-Disubstituted 4-Thio-1,2,3-triazoles and 1,5-Disubstituted 1,2,3-Triazoles

  摘要：

  AbstractOrganocatalytic azide–ketone [3+2] cycloaddition (OrgAKC) of a variety of 1‐aryl‐2‐(arylthio)ethanones and 1‐alkyl‐2‐(alkylthio)ethanones with different aryl or alkyl azides is reported in dimethyl sulfoxide or solvent‐free under ambient conditions to furnish 1,5‐disubstituted 4‐thio‐1,2,3‐triazoles in a regiospecific manner, which are further converted into useful 1,5‐disubstituted 1,2,3‐triazoles by treatment with Raney Ni at 25 °C for 1–3 h. Notable features of the OrgAKC reaction include high rate and selectivity, solvent‐free conditions, easily available substrates and catalysts, a wide range of synthetic and medicinal applications, and excellent yields generating a vast library of triazoles.

  DOI：

  10.1002/chem.201503302