4-benzyl-5-methyl-2-phenyl-1,3-thiazole | 389123-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-benzyl-5-methyl-2-phenyl-1,3-thiazole
• CAS: 389123-06-2
• 化学式: C₁₇H₁₅NS
• 分子量: 265.379
• InChiKey: CNTNRIZDVUQGRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(1-benzyl-2-oxo-propyl)-benzamide 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 0.25h， 以66%的产率得到4-benzyl-5-methyl-2-phenyl-1,3-thiazole
  参考文献：
  名称：

  Thionation ofω-Acylamino Ketones withLawesson's Reagent: Convenient Synthesis of 1,3-Thiazoles and 4H-1,3-Thiazines

  摘要：

  The reaction of omega -acylamino ketones with Lawesson's reagent (=2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide; LR) is described. Treatment of 2-acylamino ketones 1 (n = 0) with LR gave 1,3-thiazole derivatives 3 in good yields (Scheme I and Table 1). The 4H-1,3-thiazines 4 were obtained as main products by treatment of 3-acylamino ketones 2 (n = 1) with an equimolar amount of LR, while mainly the corresponding 3-(thioacyl)amino ketones 5 were isolated when 0.5 equiv. of LR was used. The 3-acylamino esters 7 also reacted with LR to give the corresponding 3-(thioacyl)amino esters 8 (Scheme 3 and Table 2).

  DOI：

  10.1002/1522-2675(20010815)84:8<2347::aid-hlca2347>3.0.co;2-n