6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
• 英文别名: 6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
• 化学式: C₁₉H₂₁F₂N₃O₄
• 分子量: 393.4
• InChiKey: HDEJSXPBDNWMNU-GXTWGEPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  73.3
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
  申请人：——

  公开号：US20030119848A1

  公开（公告）日：2003-06-26

  1 Anti-acid-fast bacterial agents containing as the active ingredient compounds represented by the general formula (1), salts thereof or hydrates of the same. Namely, pyridonecarboxylic acid derivatives having an excellent antibacterial activity on tubercle bacillus and a typical acid-fast bacteria, favorable kinetics in vivo and a high safety.

  抗酸快细菌药剂包含以一般式（1）表示的化合物作为活性成分，其盐或水合物。即，对结核杆菌和典型酸快细菌具有出色抗菌活性、在体内具有良好的动力学特性和高安全性的吡啶酮羧酸衍生物。
• Process for producing quinolonecarboxlic acids and intermediates thereof
  申请人：——

  公开号：US20030060631A1

  公开（公告）日：2003-03-27

  This invention relates to methods for the efficient production of quinolonecarboxylic acid based synthetic antibacterial agents which are expected for applications such as excellent medicaments and agricultural chemicals and to intermediate compounds to be used therein. According to the present invention, an amine substituent as the 7-position substituent of the quinolonecarboxylic acid derivative can be efficiently introduced.

  该发明涉及一种高效生产基于喹诺酮羧酸的合成抗菌剂的方法，这些抗菌剂可用于优良的药物和农业化学品等应用，并涉及用于其中的中间化合物。根据本发明，可以有效地引入喹诺酮羧酸衍生物的7位取代基作为胺基取代基。
• PROCESS FOR PRODUCING QUINOLONECARBOXYLIC ACIDS AND INTERMEDIATES THEREOF
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1258478A1

  公开（公告）日：2002-11-20

  This invention relates to methods for the efficient production of quinolonecarboxylic acid based synthetic antibacterial agents which are expected for applications such as excellent medicaments and agricultural chemicals and to intermediate compounds to be used therein. According to the present invention, an amine substituent as the 7-position substituent of the quinolonecarboxylic acid derivative can be efficiently introduced.

  本发明涉及高效生产喹啉羧酸类合成抗菌剂的方法，这种抗菌剂有望应用于优良的药物和农用化学品等领域，本发明还涉及其中使用的中间化合物。根据本发明，可以有效地引入胺取代基作为喹啉羧酸衍生物的 7 位取代基。
• ANTI-ACID-FAST BACTERIAL AGENTS CONTAINING PYRIDONECARBOXYLIC ACIDS AS THE ACTIVE INGREDIENT
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP1262477B1

  公开（公告）日：2008-09-03
• US6825353B2
  申请人：——

  公开号：US6825353B2

  公开（公告）日：2004-11-30