1-cyclohexyl-2-{2-[3-(3-pyrrolidin-1-yl-propoxy)-phenyl]-quinolin-6-yl}-1H-benzoimidazole-5-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-cyclohexyl-2-{2-[3-(3-pyrrolidin-1-yl-propoxy)-phenyl]-quinolin-6-yl}-1H-benzoimidazole-5-carboxylic acid
• 英文别名: 1-Cyclohexyl-2-[2-[3-(3-pyrrolidin-1-ylpropoxy)phenyl]-6-quinolyl]benzimidazole-5-carboxylic acid；1-cyclohexyl-2-[2-[3-(3-pyrrolidin-1-ylpropoxy)phenyl]quinolin-6-yl]benzimidazole-5-carboxylic acid
• 化学式: C₃₆H₃₈N₄O₃
• 分子量: 574.723
• InChiKey: VSBNMNFZYQQZFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  80.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• SUBSTITUTED 1-AMINOPHTHALAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF
  申请人：AUGEREAU Jean Michel

  公开号：US20090124624A1

  公开（公告）日：2009-05-14

  The invention concerns 1-amino-phthalazine derivatives of general formula (I): Wherein A, B, L, R, R 1 , R 2 , R 3 , R 4 , R 5 and R 7 are as defined herein. The invention also concerns the preparation of said compounds and their therapeutic use.

  这项发明涉及一般式(I)的1-氨基邻苯二酮衍生物：其中A、B、L、R、R1、R2、R3、R4、R5和R7如本文所定义。该发明还涉及所述化合物的制备及其治疗用途。
• Bicyclic heteroaryl derivatives
  申请人：Schmitz Ulrich Franz

  公开号：US20050187390A1

  公开（公告）日：2005-08-25

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  本发明涉及用于治疗黄病毒科病毒感染的化合物、组合物和方法。
• Therapeutic agents I
  申请人：Evertsson Emma

  公开号：US20070185079A1

  公开（公告）日：2007-08-09

  Compounds of formula(I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders, and pharmaceutical compositions containing them.

  化合物的公式(I)，制备这些化合物的过程，它们在治疗肥胖症、精神障碍、认知障碍、记忆障碍、精神分裂症、癫痫和相关疾病以及神经系统疾病如痴呆、多发性硬化症、帕金森病、亨廷顿舞蹈症和阿尔茨海默病以及与疼痛有关的疾病中的应用，以及含有它们的制药组合物。
• BICYCLIC HETEROARYL DERIVATIVES
  申请人：Schmitz Franz Ulrich

  公开号：US20090081165A1

  公开（公告）日：2009-03-26

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  本发明揭示了用于治疗黄病毒科病毒感染的化合物、组合物和方法。
• N-Piperidine Derivatives as Ccr3 Modulators
  申请人：Brickmann Kay

  公开号：US20080300232A1

  公开（公告）日：2008-12-04

  Compounds of formula I, processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders and to pharmaceutical compositions containing them.

  公式I的化合物，制备这些化合物的过程，它们在肥胖症、精神障碍、认知障碍、记忆障碍、精神分裂症、癫痫和相关疾病以及神经系统疾病如痴呆、多发性硬化症、帕金森病、亨廷顿舞蹈症和阿尔茨海默病以及与疼痛有关的疾病的治疗中的用途，以及包含它们的制药组合物。