N-(4-chlorobenzyl)-8-{3-[(2,3-dihydroxypropyl)(methyl)amino]prop-1-ynyl}-1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(4-chlorobenzyl)-8-{3-[(2,3-dihydroxypropyl)(methyl)amino]prop-1-ynyl}-1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
• 英文别名: N-[(4-chlorophenyl)methyl]-8-[3-[2,3-dihydroxypropyl(methyl)amino]prop-1-ynyl]-1-methyl-6-(morpholinomethyl)-4-oxo-quinoline-3-carboxamide；N-[(4-chlorophenyl)methyl]-8-[3-[2,3-dihydroxypropyl(methyl)amino]prop-1-ynyl]-1-methyl-6-(morpholin-4-ylmethyl)-4-oxoquinoline-3-carboxamide
• 化学式: C₃₀H₃₅ClN₄O₅
• 分子量: 567.085
• InChiKey: WZDNQHUHVQSJHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Substituted quinolinecarboxamides as antiviral agents
  申请人：——

  公开号：US20020165253A1

  公开（公告）日：2002-11-07

  The present invention discloses disubstiuted 4-oxo-1,4-dihydro-3-quinolinecarboxamide derivatives. The compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明公开了二取代的4-氧代-1,4-二氢-3-喹啉羧酰胺衍生物。这些化合物可用作抗病毒剂，特别是用于抗击疱疹病毒家族的药剂。
• SUBSTITUTED QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1363887A1

  公开（公告）日：2003-11-26
• US6544990B2
  申请人：——

  公开号：US6544990B2

  公开（公告）日：2003-04-08
• US6727248B2
  申请人：——

  公开号：US6727248B2

  公开（公告）日：2004-04-27
• [EN] SUBSTITUTED QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS<br/>[FR] ANTIVIRAUX À BASE DE QUINOLINECARBOXAMIDES SUBSTITUÉES
  申请人：UPJOHN CO

  公开号：WO2002070487A1

  公开（公告）日：2002-09-12

  The present invention discloses disubstituted 4-oxo-1,4-dihydro-3-quinolinecarboxamide derivatives. The compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.